ID   HRCA_CORA7              Reviewed;         344 AA.
AC   C3PHU9;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   16-JUN-2009, sequence version 1.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=cauri_1810;
OS   Corynebacterium aurimucosum (strain ATCC 700975 / DSM 44827 / CIP 107346 /
OS   CN-1) (Corynebacterium nigricans).
OC   Bacteria; Actinobacteria; Corynebacteriales; Corynebacteriaceae;
OC   Corynebacterium.
OX   NCBI_TaxID=548476;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700975 / DSM 44827 / CIP 107346 / CN-1;
RX   PubMed=20137072; DOI=10.1186/1471-2164-11-91;
RA   Trost E., Gotker S., Schneider J., Schneiker-Bekel S., Szczepanowski R.,
RA   Tilker A., Viehoever P., Arnold W., Bekel T., Blom J., Gartemann K.H.,
RA   Linke B., Goesmann A., Puhler A., Shukla S.K., Tauch A.;
RT   "Complete genome sequence and lifestyle of black-pigmented Corynebacterium
RT   aurimucosum ATCC 700975 (formerly C. nigricans CN-1) isolated from a
RT   vaginal swab of a woman with spontaneous abortion.";
RL   BMC Genomics 11:91-91(2010).
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; CP001601; ACP33403.1; -; Genomic_DNA.
DR   RefSeq; WP_010190776.1; NZ_ACLH01000091.1.
DR   AlphaFoldDB; C3PHU9; -.
DR   SMR; C3PHU9; -.
DR   STRING; 548476.cauri_1810; -.
DR   EnsemblBacteria; ACP33403; ACP33403; cauri_1810.
DR   GeneID; 31924444; -.
DR   KEGG; car:cauri_1810; -.
DR   eggNOG; COG1420; Bacteria.
DR   HOGENOM; CLU_050019_2_0_11; -.
DR   OMA; DYPGTMG; -.
DR   OrthoDB; 1510750at2; -.
DR   Proteomes; UP000002077; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR001034; DeoR_HTH.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   Pfam; PF08220; HTH_DeoR; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repressor; Stress response; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..344
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_1000118297"
SQ   SEQUENCE   344 AA;  37066 MW;  732351B2D166F96D CRC64;
     MSSSTDARRQ EVLRAIVADY IASQSPVGSK ALLERYQLGV SSATIRNDMA VLEAEGLIAQ
     EHASSGRVPT QKGYRQFVDT LHDVKPLSKA ERRAMLTFLE GGVDLEDVLR RSVQLLAQVT
     KQAAVVQLPN LKVSRVKHCE VVALSPVRLL LVLITDNGRV DQRNVELDDV IDPEQTHRLR
     DILNTALEGK TLTEASVELA ALVDDSPADI RPHLLKAATT LIETLVEQPS DRLIMAGTSN
     LTRVALTEGL PSIIEALEEQ VVVLKLLARV PDLGNVSVSI GEENEADELR QTSVVATRYG
     FGTGSEAAAL GGLGVVGPTY MDYSGTISKV SAVARYVSEI LAGE