ID   HRCA_COREF              Reviewed;         342 AA.
AC   Q8FNF4;
DT   26-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2004, sequence version 2.
DT   25-MAY-2022, entry version 96.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=CE2190;
OS   Corynebacterium efficiens (strain DSM 44549 / YS-314 / AJ 12310 / JCM 11189
OS   / NBRC 100395).
OC   Bacteria; Actinobacteria; Corynebacteriales; Corynebacteriaceae;
OC   Corynebacterium.
OX   NCBI_TaxID=196164;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395;
RX   PubMed=12840036; DOI=10.1101/gr.1285603;
RA   Nishio Y., Nakamura Y., Kawarabayasi Y., Usuda Y., Kimura E., Sugimoto S.,
RA   Matsui K., Yamagishi A., Kikuchi H., Ikeo K., Gojobori T.;
RT   "Comparative complete genome sequence analysis of the amino acid
RT   replacements responsible for the thermostability of Corynebacterium
RT   efficiens.";
RL   Genome Res. 13:1572-1579(2003).
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAC19000.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; BA000035; BAC19000.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_006768193.1; NZ_GG700683.1.
DR   AlphaFoldDB; Q8FNF4; -.
DR   SMR; Q8FNF4; -.
DR   STRING; 196164.23494032; -.
DR   EnsemblBacteria; BAC19000; BAC19000; BAC19000.
DR   KEGG; cef:CE2190; -.
DR   eggNOG; COG1420; Bacteria.
DR   HOGENOM; CLU_050019_2_0_11; -.
DR   OrthoDB; 1510750at2; -.
DR   Proteomes; UP000001409; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR013196; HTH_11.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   Pfam; PF08279; HTH_11; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repressor; Stress response; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..342
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_0000182475"
SQ   SEQUENCE   342 AA;  37058 MW;  D0F636CF6675BDBA CRC64;
     MASATEKRRY EVLRAIVADY IESQEPVGSK ALLERHKLNV SSATIRNDMS VLESDGYIVQ
     EHASSGRVPT EKGYRLFVDS IHDIKPLSLA ERRAILGFLE GGVDLEDVLR RSVQLLSQLT
     HQAAVVQLPT LKTARVKHCE VVSLSPVRLL LVLITDTGRV DQRNVELDEP LEADQVTVLK
     DLLNGALAEK TLTDASEALQ ELSRNAPSDI RSTMEKCSGV LVATLVEQPS DRLILAGASN
     LTRLTRETAA SVPMVLEALE EQVVMLKLLS NVTDLDHVTV HIGEENEDLQ LRSASVVTTG
     YGSAGNTLGG LGVVGPTYMD YPGTISKVSA VARYVGRVLA GE