ID   HRCA_CORGB              Reviewed;         342 AA.
AC   A4QFZ9;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   15-MAY-2007, sequence version 1.
DT   25-MAY-2022, entry version 86.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=cgR_2163;
OS   Corynebacterium glutamicum (strain R).
OC   Bacteria; Actinobacteria; Corynebacteriales; Corynebacteriaceae;
OC   Corynebacterium.
OX   NCBI_TaxID=340322;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=R;
RX   PubMed=17379713; DOI=10.1099/mic.0.2006/003657-0;
RA   Yukawa H., Omumasaba C.A., Nonaka H., Kos P., Okai N., Suzuki N., Suda M.,
RA   Tsuge Y., Watanabe J., Ikeda Y., Vertes A.A., Inui M.;
RT   "Comparative analysis of the Corynebacterium glutamicum group and complete
RT   genome sequence of strain R.";
RL   Microbiology 153:1042-1058(2007).
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; AP009044; BAF55165.1; -; Genomic_DNA.
DR   RefSeq; WP_003859450.1; NC_009342.1.
DR   AlphaFoldDB; A4QFZ9; -.
DR   SMR; A4QFZ9; -.
DR   EnsemblBacteria; BAF55165; BAF55165; cgR_2163.
DR   GeneID; 58310907; -.
DR   KEGG; cgt:cgR_2163; -.
DR   HOGENOM; CLU_050019_2_0_11; -.
DR   OMA; DYPGTMG; -.
DR   PhylomeDB; A4QFZ9; -.
DR   Proteomes; UP000006698; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Repressor; Stress response; Transcription; Transcription regulation.
FT   CHAIN           1..342
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_1000118298"
SQ   SEQUENCE   342 AA;  37191 MW;  15711C5AC342D5B8 CRC64;
     MVSATEKRRY EVLRAIVADY IASQEPVGSK SLLERHKLNV SSATIRNDMS VLESDGFIVQ
     EHASSGRVPT ERGYRLFVDS IHDIKPLSLA ERRAILGFLE GGVDLEDVLR RSVQLLSQLT
     HQAAVVQLPT LKTARVKHCE VVPLSPMRLL LVLITDTGRV DQRNVELEEP LAAEEVNVLR
     DLLNGALGEK TLTAASDALE ELAQQAPTDI RDAMRRCCDV LVNTLVDQPS DRLILAGTSN
     LTRLSRETSA SLPMVLEALE EQVVMLKLLS NVTDLDQVRV HIGGENEDIE LRSATVITTG
     YGSQGSALGG LGVVGPTYMD YSGTISKVSA VAKYVGRVLA GE