ID   HRCA_CORJK              Reviewed;         341 AA.
AC   Q4JWP8;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   02-AUG-2005, sequence version 1.
DT   25-MAY-2022, entry version 103.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=jk0600;
OS   Corynebacterium jeikeium (strain K411).
OC   Bacteria; Actinobacteria; Corynebacteriales; Corynebacteriaceae;
OC   Corynebacterium.
OX   NCBI_TaxID=306537;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K411;
RX   PubMed=15968079; DOI=10.1128/jb.187.13.4671-4682.2005;
RA   Tauch A., Kaiser O., Hain T., Goesmann A., Weisshaar B., Albersmeier A.,
RA   Bekel T., Bischoff N., Brune I., Chakraborty T., Kalinowski J., Meyer F.,
RA   Rupp O., Schneiker S., Viehoever P., Puehler A.;
RT   "Complete genome sequence and analysis of the multiresistant nosocomial
RT   pathogen Corynebacterium jeikeium K411, a lipid-requiring bacterium of the
RT   human skin flora.";
RL   J. Bacteriol. 187:4671-4682(2005).
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; CR931997; CAI36759.1; -; Genomic_DNA.
DR   RefSeq; WP_011273244.1; NC_007164.1.
DR   AlphaFoldDB; Q4JWP8; -.
DR   SMR; Q4JWP8; -.
DR   STRING; 306537.jk0600; -.
DR   EnsemblBacteria; CAI36759; CAI36759; jk0600.
DR   KEGG; cjk:jk0600; -.
DR   PATRIC; fig|306537.10.peg.611; -.
DR   eggNOG; COG1420; Bacteria.
DR   HOGENOM; CLU_050019_2_0_11; -.
DR   OMA; DYPGTMG; -.
DR   OrthoDB; 1510750at2; -.
DR   Proteomes; UP000000545; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR001034; DeoR_HTH.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   Pfam; PF08220; HTH_DeoR; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repressor; Stress response; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..341
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_1000010402"
SQ   SEQUENCE   341 AA;  37298 MW;  CBF846CD2E5AEC75 CRC64;
     MSSGTEHRRN QVLRAIVSDF IASHEPVGSK MLVDRHQLGV SSATIRNDMA VLEAEGYITQ
     QHASSGRIPT VKGYRRFVDG INEVKPLSTP ERRAILDFLE HGVDLEDVLR RSVQLLSQLT
     RQVAVVQMPD LRRGRVKHCE LVKLGSHRIL LVLITDTGRV DQRNVDLGQP ISDDDLPRLR
     DLVNSAMVGR TLDDACTNIA ALANEAKGNS MPEELRDVAL VVTTVLVETL LERPNDRLIL
     AGTPNLMRTS ELSPVVEALE EQVVVLKLLN SVRDLQVQVS IGEENEDEEL RGASVVSTGY
     GNANAVLGGM GVVGPTHLDY SGTISSVTAV AHYVSRILSE E