ID   HRCA_CYAP4              Reviewed;         364 AA.
AC   B8HQ19;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   03-MAR-2009, sequence version 1.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   OrderedLocusNames=Cyan7425_5123;
OS   Cyanothece sp. (strain PCC 7425 / ATCC 29141).
OC   Bacteria; Cyanobacteria; Oscillatoriophycideae; Oscillatoriales;
OC   Cyanothecaceae; Cyanothece; unclassified Cyanothece.
OX   NCBI_TaxID=395961;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PCC 7425 / ATCC 29141;
RX   PubMed=21972240; DOI=10.1128/mbio.00214-11;
RA   Bandyopadhyay A., Elvitigala T., Welsh E., Stockel J., Liberton M., Min H.,
RA   Sherman L.A., Pakrasi H.B.;
RT   "Novel metabolic attributes of the genus Cyanothece, comprising a group of
RT   unicellular nitrogen-fixing Cyanobacteria.";
RL   MBio 2:E214-E214(2011).
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; CP001344; ACL47416.1; -; Genomic_DNA.
DR   RefSeq; WP_012630445.1; NC_011884.1.
DR   AlphaFoldDB; B8HQ19; -.
DR   SMR; B8HQ19; -.
DR   STRING; 395961.Cyan7425_5123; -.
DR   EnsemblBacteria; ACL47416; ACL47416; Cyan7425_5123.
DR   KEGG; cyn:Cyan7425_5123; -.
DR   eggNOG; COG1420; Bacteria.
DR   HOGENOM; CLU_050019_1_0_3; -.
DR   OMA; DYPGTMG; -.
DR   OrthoDB; 1510750at2; -.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Repressor; Stress response; Transcription; Transcription regulation.
FT   CHAIN           1..364
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_1000118299"
SQ   SEQUENCE   364 AA;  40784 MW;  D905B539ACE4BE07 CRC64;
     MQVRLNERQQ QVLWATVRHY IATAEPVGSK ALAEEYNLKV SAATIRNIMG ALEQGGLLYQ
     PHTSAGRVPS DSGYRIYVDY LMTPANDLSR RVEQLLSDRL NPTSISLEAV LRGAAQILAT
     LSGYITLITL PQTLTATIRW LQLVRVETSR VMLIVVTDNY ETRSALMELG DTADTEESRI
     ERELEVLTNF LNHQLRGRSL TELANLDWQQ LDREFQRHGD TLRTLLQDLL QRSQPVGSNQ
     ILISGLSEVL QQPEFSQLQQ VQTILHLLED EQDQLWPLIC EWSVATDAAP ITLPSQQRVR
     ILIGSENPLE PMRMCTLVSS TYQRGSVPIG SVGVLGPTRM PYDKVIPLVE ATADYLSDTL
     GQPA