ID   AP1S2_BOVIN             Reviewed;         160 AA.
AC   Q3ZBS3;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   27-SEP-2005, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=AP-1 complex subunit sigma-2;
DE   AltName: Full=Adaptor protein complex AP-1 subunit sigma-1B;
DE   AltName: Full=Adaptor-related protein complex 1 subunit sigma-1B;
DE   AltName: Full=Clathrin assembly protein complex 1 sigma-1B small chain;
DE   AltName: Full=Golgi adaptor HA1/AP1 adaptin sigma-1B subunit;
DE   AltName: Full=Sigma 1B subunit of AP-1 clathrin;
DE   AltName: Full=Sigma-adaptin 1B;
DE   AltName: Full=Sigma1B-adaptin;
GN   Name=AP1S2;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Hypothalamus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Subunit of clathrin-associated adaptor protein complex 1 that
CC       plays a role in protein sorting in the late-Golgi/trans-Golgi network
CC       (TGN) and/or endosomes. The AP complexes mediate both the recruitment
CC       of clathrin to membranes and the recognition of sorting signals within
CC       the cytosolic tails of transmembrane cargo molecules (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Adaptor protein complex 1 (AP-1) is a heterotetramer composed
CC       of two large adaptins (gamma-type subunit AP1G1 and beta-type subunit
CC       AP1B1), a medium adaptin (mu-type subunit AP1M1 or AP1M2) and a small
CC       adaptin (sigma-type subunit AP1S1 or AP1S2 or AP1S3). Binds to MUC1 (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus. Cytoplasmic vesicle membrane
CC       {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic
CC       side {ECO:0000250}. Membrane, clathrin-coated pit {ECO:0000250}.
CC       Note=Component of the coat surrounding the cytoplasmic face of coated
CC       vesicles located at the Golgi complex. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the adaptor complexes small subunit family.
CC       {ECO:0000305}.
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DR   EMBL; BC103139; AAI03140.1; -; mRNA.
DR   RefSeq; NP_001035681.1; NM_001040591.2.
DR   AlphaFoldDB; Q3ZBS3; -.
DR   SMR; Q3ZBS3; -.
DR   STRING; 9913.ENSBTAP00000027212; -.
DR   PaxDb; Q3ZBS3; -.
DR   PRIDE; Q3ZBS3; -.
DR   Ensembl; ENSBTAT00000027212; ENSBTAP00000027212; ENSBTAG00000020420.
DR   GeneID; 616331; -.
DR   KEGG; bta:616331; -.
DR   CTD; 8905; -.
DR   VEuPathDB; HostDB:ENSBTAG00000020420; -.
DR   VGNC; VGNC:50199; AP1S2.
DR   eggNOG; KOG0934; Eukaryota.
DR   GeneTree; ENSGT00970000193372; -.
DR   HOGENOM; CLU_061221_1_3_1; -.
DR   InParanoid; Q3ZBS3; -.
DR   OrthoDB; 1307450at2759; -.
DR   TreeFam; TF312921; -.
DR   Proteomes; UP000009136; Chromosome X.
DR   Bgee; ENSBTAG00000020420; Expressed in pigment epithelium of eye and 107 other tissues.
DR   ExpressionAtlas; Q3ZBS3; baseline and differential.
DR   GO; GO:0030121; C:AP-1 adaptor complex; IEA:InterPro.
DR   GO; GO:0005905; C:clathrin-coated pit; IEA:UniProtKB-SubCell.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR   GO; GO:0035615; F:clathrin adaptor activity; IEA:InterPro.
DR   GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR   GO; GO:0016192; P:vesicle-mediated transport; IBA:GO_Central.
DR   CDD; cd14831; AP1_sigma; 1.
DR   InterPro; IPR044733; AP1_sigma.
DR   InterPro; IPR016635; AP_complex_ssu.
DR   InterPro; IPR022775; AP_mu_sigma_su.
DR   InterPro; IPR000804; Clathrin_sm-chain_CS.
DR   InterPro; IPR011012; Longin-like_dom_sf.
DR   PANTHER; PTHR11753; PTHR11753; 1.
DR   Pfam; PF01217; Clat_adaptor_s; 1.
DR   PIRSF; PIRSF015588; AP_complex_sigma; 1.
DR   SUPFAM; SSF64356; SSF64356; 1.
DR   PROSITE; PS00989; CLAT_ADAPTOR_S; 1.
PE   2: Evidence at transcript level;
KW   Coated pit; Cytoplasmic vesicle; Golgi apparatus; Membrane;
KW   Protein transport; Reference proteome; Transport.
FT   CHAIN           1..160
FT                   /note="AP-1 complex subunit sigma-2"
FT                   /id="PRO_0000323379"
SQ   SEQUENCE   160 AA;  18929 MW;  31435A74AAF476E8 CRC64;
     MQFMLLFSRQ GKLRLQKWYV PLSDKEKKKI TRELVQTVLA RKPKMCSFLE WRDLKIVYKR
     YASLYFCCAI EDQDNELITL EIIHRYVELL DKYFGSVCEL DIIFNFEKAY FILDEFLLGG
     EVQETSKKNV LKAIEQADLL QEDAKEAETP RSVLEEIGLT