ID   HRCA_DEHM1              Reviewed;         345 AA.
AC   Q3Z6N9;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   27-SEP-2005, sequence version 1.
DT   25-MAY-2022, entry version 94.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=DET1401;
OS   Dehalococcoides mccartyi (strain ATCC BAA-2266 / KCTC 15142 / 195)
OS   (Dehalococcoides ethenogenes (strain 195)).
OC   Bacteria; Chloroflexi; Dehalococcoidia; Dehalococcoidales;
OC   Dehalococcoidaceae; Dehalococcoides.
OX   NCBI_TaxID=243164;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-2266 / KCTC 15142 / 195;
RX   PubMed=15637277; DOI=10.1126/science.1102226;
RA   Seshadri R., Adrian L., Fouts D.E., Eisen J.A., Phillippy A.M., Methe B.A.,
RA   Ward N.L., Nelson W.C., DeBoy R.T., Khouri H.M., Kolonay J.F., Dodson R.J.,
RA   Daugherty S.C., Brinkac L.M., Sullivan S.A., Madupu R., Nelson K.E.,
RA   Kang K.H., Impraim M., Tran K., Robinson J.M., Forberger H.A., Fraser C.M.,
RA   Zinder S.H., Heidelberg J.F.;
RT   "Genome sequence of the PCE-dechlorinating bacterium Dehalococcoides
RT   ethenogenes.";
RL   Science 307:105-108(2005).
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; CP000027; AAW39349.1; -; Genomic_DNA.
DR   RefSeq; WP_010937087.1; NC_002936.3.
DR   AlphaFoldDB; Q3Z6N9; -.
DR   SMR; Q3Z6N9; -.
DR   STRING; 243164.DET1401; -.
DR   EnsemblBacteria; AAW39349; AAW39349; DET1401.
DR   KEGG; det:DET1401; -.
DR   PATRIC; fig|243164.10.peg.1328; -.
DR   eggNOG; COG1420; Bacteria.
DR   HOGENOM; CLU_050019_0_0_0; -.
DR   OMA; DYPGTMG; -.
DR   OrthoDB; 1510750at2; -.
DR   Proteomes; UP000008289; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repressor; Stress response; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..345
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_1000010404"
SQ   SEQUENCE   345 AA;  39093 MW;  54114CAD88B114AB CRC64;
     MLTPRAEIIL RSIVRQYITK AVPVSSSSIL EDCGLDICSA TIRNEVVRLE TEGYILRPHH
     SAGSIPADKG YRYYVESLKD VELPTNDKFL IRHLFHQVEK EMEEWLNLTV AVLSQRVQSM
     AVVTMPRQTQ GKVHHIELVS LQDNLVLVVL ILRGAKVKQQ LINFENTVSQ PELTLISNRL
     NDAYAGLTRF QIEQKTLNLN PDELKVKDSL IKMMRGEDEQ ESREPFFDGL HYMLEQPEFH
     QNQRVQEIMQ LLEQKKLSKM IAPPSPFNRG VQVYIGQENA SAEIRDYSLI VSQYGIPDEA
     VGTIGVIGPT RMAYERALSA VSYLSLVMST LVAELYGKPP GGKDE