ID   HRCA_DEHMB              Reviewed;         345 AA.
AC   A5FPT3;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   12-JUN-2007, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   OrderedLocusNames=DehaBAV1_1210;
OS   Dehalococcoides mccartyi (strain ATCC BAA-2100 / JCM 16839 / KCTC 5957 /
OS   BAV1).
OC   Bacteria; Chloroflexi; Dehalococcoidia; Dehalococcoidales;
OC   Dehalococcoidaceae; Dehalococcoides.
OX   NCBI_TaxID=216389;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-2100 / JCM 16839 / KCTC 5957 / BAV1;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Pitluck S., Lowry S., Clum A.,
RA   Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E.,
RA   Ritalahti K.M., Loeffler F., Richardson P.;
RT   "Complete sequence of Dehalococcoides sp. BAV1.";
RL   Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; CP000688; ABQ17789.1; -; Genomic_DNA.
DR   RefSeq; WP_011309760.1; NC_009455.1.
DR   AlphaFoldDB; A5FPT3; -.
DR   SMR; A5FPT3; -.
DR   KEGG; deb:DehaBAV1_1210; -.
DR   PATRIC; fig|216389.18.peg.1277; -.
DR   HOGENOM; CLU_050019_0_0_0; -.
DR   OMA; DYPGTMG; -.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Repressor; Stress response; Transcription; Transcription regulation.
FT   CHAIN           1..345
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_1000075287"
SQ   SEQUENCE   345 AA;  39206 MW;  4CF935F45276E524 CRC64;
     MLTSRAEIIL RSIVRQYITK AVPVSSSSIL EDCGLDICSA TIRNEVVRLE IEGYILRPHH
     SAGSIPADKG YRYYVESLKD VELPTNDKFL IRHLFHQVEK EMEEWLNLTV AVLSQRVQSM
     AVVTMPRQTQ GKVHHIELVS LQDNLVLVVL ILRGAKVKQQ LVNFENVVSQ PELTLISNRL
     NDAYDGLTRF QIEQKPLGLN HDELKVKDSL VKMMRGEDEQ ESREPFFDGL HYMLEQPEFH
     QNQRAQEIMQ LLEQKKLSKM IVPPMPFNRG VQVYIGQENA SAEIRDYSLI VSQYGIPDEA
     VGTIGVIGPT RMAYERALSA VSYLSLVMST LVAELYGKAP VDKDE