ID   HRCA_DEHMC              Reviewed;         345 AA.
AC   Q3ZYU9;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   27-SEP-2005, sequence version 1.
DT   25-MAY-2022, entry version 94.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=cbdbA1361;
OS   Dehalococcoides mccartyi (strain CBDB1).
OC   Bacteria; Chloroflexi; Dehalococcoidia; Dehalococcoidales;
OC   Dehalococcoidaceae; Dehalococcoides.
OX   NCBI_TaxID=255470;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBDB1;
RX   PubMed=16116419; DOI=10.1038/nbt1131;
RA   Kube M., Beck A., Zinder S.H., Kuhl H., Reinhardt R., Adrian L.;
RT   "Genome sequence of the chlorinated compound-respiring bacterium
RT   Dehalococcoides species strain CBDB1.";
RL   Nat. Biotechnol. 23:1269-1273(2005).
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; AJ965256; CAI83409.1; -; Genomic_DNA.
DR   RefSeq; WP_011309760.1; NC_007356.1.
DR   AlphaFoldDB; Q3ZYU9; -.
DR   SMR; Q3ZYU9; -.
DR   KEGG; deh:cbdbA1361; -.
DR   HOGENOM; CLU_050019_0_0_0; -.
DR   OMA; DYPGTMG; -.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Repressor; Stress response; Transcription; Transcription regulation.
FT   CHAIN           1..345
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_1000010405"
SQ   SEQUENCE   345 AA;  39206 MW;  4CF935F45276E524 CRC64;
     MLTSRAEIIL RSIVRQYITK AVPVSSSSIL EDCGLDICSA TIRNEVVRLE IEGYILRPHH
     SAGSIPADKG YRYYVESLKD VELPTNDKFL IRHLFHQVEK EMEEWLNLTV AVLSQRVQSM
     AVVTMPRQTQ GKVHHIELVS LQDNLVLVVL ILRGAKVKQQ LVNFENVVSQ PELTLISNRL
     NDAYDGLTRF QIEQKPLGLN HDELKVKDSL VKMMRGEDEQ ESREPFFDGL HYMLEQPEFH
     QNQRAQEIMQ LLEQKKLSKM IVPPMPFNRG VQVYIGQENA SAEIRDYSLI VSQYGIPDEA
     VGTIGVIGPT RMAYERALSA VSYLSLVMST LVAELYGKAP VDKDE