ID   HRCA_DELAS              Reviewed;         334 AA.
AC   A9BP03;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   15-JAN-2008, sequence version 1.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=Daci_5419;
OS   Delftia acidovorans (strain DSM 14801 / SPH-1).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Comamonadaceae; Delftia.
OX   NCBI_TaxID=398578;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 14801 / SPH-1;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA   Tice H., Pitluck S., Lowry S., Clum A., Schmutz J., Larimer F., Land M.,
RA   Hauser L., Kyrpides N., Kim E., Schleheck D., Richardson P.;
RT   "Complete sequence of Delftia acidovorans DSM 14801 / SPH-1.";
RL   Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; CP000884; ABX38048.1; -; Genomic_DNA.
DR   RefSeq; WP_012207217.1; NC_010002.1.
DR   AlphaFoldDB; A9BP03; -.
DR   SMR; A9BP03; -.
DR   STRING; 398578.Daci_5419; -.
DR   PRIDE; A9BP03; -.
DR   EnsemblBacteria; ABX38048; ABX38048; Daci_5419.
DR   KEGG; dac:Daci_5419; -.
DR   eggNOG; COG1420; Bacteria.
DR   HOGENOM; CLU_050019_0_0_4; -.
DR   OMA; DYPGTMG; -.
DR   Proteomes; UP000000784; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR005104; WHTH_HrcA_DNA-bd.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   Pfam; PF03444; HrcA_DNA-bdg; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repressor; Stress response; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..334
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_1000118300"
SQ   SEQUENCE   334 AA;  36814 MW;  07F552F2F5AEFBE2 CRC64;
     MLDERAKLLL KALIERYIAD GQPVGSRTLS RASGLELSPA TIRNVMADLE DLGLIISPHT
     SAGRIPTARG YRLFVDTMLT ADRADIVTPE LVPEQPQKVI ANAANLLSSL SQFVGVVLVP
     RRTSVFKHIE FVRLSERRFL VIIVSPDGDV QNRVIFTDVD YSSSQLIEAS NFLNSHYAGL
     AMEEVRERLK GEVELLRGEV ATLMQAAVNI GTEAMTSAQE DVVIAGERNL LSVSDFSSDM
     GNLRRAFDLF EQKTQILRLL DFSSQAEGVR IYIGGESQVV PFEELSVVSA PYELDGKVVG
     TLGVIGPTRM HYDRMIQIVD ITSKLVSNAL SHKR