ID   HRCA_DESAP              Reviewed;         344 AA.
AC   B1I6D9;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   29-APR-2008, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=Daud_2060;
OS   Desulforudis audaxviator (strain MP104C).
OC   Bacteria; Firmicutes; Clostridia; Eubacteriales; Peptococcaceae;
OC   Candidatus Desulforudis.
OX   NCBI_TaxID=477974;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MP104C;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA   Tice H., Bruce D., Pitluck S., Lowry S.R., Larimer F., Land M.L.,
RA   Hauser L., Kyrpides N., Ivanova N.N., Richardson P.;
RT   "Complete sequence of chromosome of Desulforudis audaxviator MP104C.";
RL   Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; CP000860; ACA60550.1; -; Genomic_DNA.
DR   RefSeq; WP_012303125.1; NC_010424.1.
DR   AlphaFoldDB; B1I6D9; -.
DR   SMR; B1I6D9; -.
DR   STRING; 477974.Daud_2060; -.
DR   PRIDE; B1I6D9; -.
DR   EnsemblBacteria; ACA60550; ACA60550; Daud_2060.
DR   KEGG; dau:Daud_2060; -.
DR   eggNOG; COG1420; Bacteria.
DR   HOGENOM; CLU_050019_1_0_9; -.
DR   OMA; DYPGTMG; -.
DR   OrthoDB; 1510750at2; -.
DR   Proteomes; UP000008544; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repressor; Stress response; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..344
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_1000092808"
SQ   SEQUENCE   344 AA;  38368 MW;  2C0CE2AAF3CFBC7B CRC64;
     MGIDERKKQI LRAIVLDYIA TAEPVGSRTI ARKYGLGISP ATIRNEMADL EEMGYLEQPH
     TSAGRIPSQR GYRYYVDELM EPETPAEEEK LIIKTNYQAK VKSISEVIER TGQLMSQLTS
     YAALVSTPRV TGSTVQHVQL IAMGGGKAMV LVVTEPEKVH TRVIDLPENI TAEDLETVSR
     VMNAKIRGHS LNDIRITILR EIYLELLRHK AVVEYIMDLI EDSGESTEDR VYLGGILNIL
     NQPEFRNVEK MKTLLSLLDQ EALLSSLLAE QAGQEEGITV LIGDEFKCDL IQGCSLVSAR
     YGVEGRAVGA LAVLGPSRMD YARVTGLVEY LTRNLSRVLE KLYR