ID   HRCA_DESVH              Reviewed;         355 AA.
AC   Q72DW6;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=DVU_0813;
OS   Desulfovibrio vulgaris (strain ATCC 29579 / DSM 644 / NCIMB 8303 / VKM
OS   B-1760 / Hildenborough).
OC   Bacteria; Proteobacteria; Deltaproteobacteria; Desulfovibrionales;
OC   Desulfovibrionaceae; Desulfovibrio.
OX   NCBI_TaxID=882;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29579 / DSM 644 / NCIMB 8303 / VKM B-1760 / Hildenborough;
RX   PubMed=15077118; DOI=10.1038/nbt959;
RA   Heidelberg J.F., Seshadri R., Haveman S.A., Hemme C.L., Paulsen I.T.,
RA   Kolonay J.F., Eisen J.A., Ward N.L., Methe B.A., Brinkac L.M.,
RA   Daugherty S.C., DeBoy R.T., Dodson R.J., Durkin A.S., Madupu R.,
RA   Nelson W.C., Sullivan S.A., Fouts D.E., Haft D.H., Selengut J.,
RA   Peterson J.D., Davidsen T.M., Zafar N., Zhou L., Radune D., Dimitrov G.,
RA   Hance M., Tran K., Khouri H.M., Gill J., Utterback T.R., Feldblyum T.V.,
RA   Wall J.D., Voordouw G., Fraser C.M.;
RT   "The genome sequence of the anaerobic, sulfate-reducing bacterium
RT   Desulfovibrio vulgaris Hildenborough.";
RL   Nat. Biotechnol. 22:554-559(2004).
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; AE017285; AAS95293.1; -; Genomic_DNA.
DR   RefSeq; WP_010938114.1; NC_002937.3.
DR   RefSeq; YP_010034.1; NC_002937.3.
DR   AlphaFoldDB; Q72DW6; -.
DR   SMR; Q72DW6; -.
DR   STRING; 882.DVU_0813; -.
DR   PaxDb; Q72DW6; -.
DR   PRIDE; Q72DW6; -.
DR   EnsemblBacteria; AAS95293; AAS95293; DVU_0813.
DR   KEGG; dvu:DVU_0813; -.
DR   PATRIC; fig|882.5.peg.763; -.
DR   eggNOG; COG1420; Bacteria.
DR   HOGENOM; CLU_050019_0_0_7; -.
DR   OMA; DYPGTMG; -.
DR   PhylomeDB; Q72DW6; -.
DR   Proteomes; UP000002194; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repressor; Stress response; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..355
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_0000182477"
SQ   SEQUENCE   355 AA;  38550 MW;  0F5C34ACAA242A2D CRC64;
     MSALGSRETH VLTTIIESYI TSAAPVGSRT VSRRSGLALS PASMRNTMSD LTDMGFLEQP
     HTSAGRIPTP KAFRLYVDAL LRQSARRDEA PLHMVEALHG HEPEVGALLR RASNLVSEHA
     RQVSMVLAPG PAEARLRSLD FVPAGEGLVL AVLVLEGGMV RTRLVRDDTH FGSDELVRFG
     NYINAHYRGH TLSGIRNSIH HELSGGGAQL EAMCAQALAL GSLALDSIDD DRELYVNGTR
     NILDQAEFAE LGRMRELMDA LEERSRLLEL LDRTILEDDV HVTFYPDDVS GGAQRRAPDG
     LRGCSMVSAP YGGASPLGVI GVIGPVRMDY RKVLPLVGAV SRVLTQLLRE RFATG