ID   HRCA_DESVM              Reviewed;         355 AA.
AC   B8DKI5;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   03-MAR-2009, sequence version 1.
DT   03-AUG-2022, entry version 64.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=DvMF_1195;
OS   Desulfovibrio vulgaris (strain DSM 19637 / Miyazaki F).
OC   Bacteria; Proteobacteria; Deltaproteobacteria; Desulfovibrionales;
OC   Desulfovibrionaceae; Desulfovibrio.
OX   NCBI_TaxID=883;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 19637 / Miyazaki F;
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA   Bruce D., Goodwin L., Pitluck S., Sims D., Brettin T., Detter J.C., Han C.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Hazen T.C.,
RA   Richardson P.;
RT   "Complete sequence of Desulfovibrio vulgaris str. 'Miyazaki F'.";
RL   Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; CP001197; ACL08147.1; -; Genomic_DNA.
DR   RefSeq; WP_012612336.1; NC_011769.1.
DR   AlphaFoldDB; B8DKI5; -.
DR   SMR; B8DKI5; -.
DR   STRING; 883.DvMF_1195; -.
DR   EnsemblBacteria; ACL08147; ACL08147; DvMF_1195.
DR   KEGG; dvm:DvMF_1195; -.
DR   eggNOG; COG1420; Bacteria.
DR   HOGENOM; CLU_050019_1_0_7; -.
DR   OMA; DYPGTMG; -.
DR   OrthoDB; 1510750at2; -.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Repressor; Stress response; Transcription; Transcription regulation.
FT   CHAIN           1..355
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_1000117110"
SQ   SEQUENCE   355 AA;  38951 MW;  74B59B9C5CC09E90 CRC64;
     MPSLGQRETQ VLATIIESYI ASASPVGSRA VAEHSGLHLS PASMRATMSD LTDLGYLEQP
     HTSAGRVPTA RAFRLYVDSL LRPLPLGSAE RDAIADELSR QELEISGILR RAANLLSGHA
     RQLGMVVAPS EDEARWRSIE FAPAAEGLVL AVLMLEGGLV RTRTVRVDER YGQDELVRFG
     NYLNEHFRGL SLSEARDRIG HELARAGSRL EEMCVRALAL SRRAVEHMGD DRELIVNGTL
     NMLDHAEFTD VGRMRDLLAA IEERSRLLEL LDRTLSERDV RITFCQDVAD GAPDGLRGCS
     VISAAYGGDT PRGVVSVVGP LRMDYAKIVP VVQCVSRALT QLFRERFAAA PCRLP