ID   HRCA_DESVV              Reviewed;         355 AA.
AC   A1VFG4;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2007, sequence version 1.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=Dvul_2164;
OS   Desulfovibrio vulgaris subsp. vulgaris (strain DP4).
OC   Bacteria; Proteobacteria; Deltaproteobacteria; Desulfovibrionales;
OC   Desulfovibrionaceae; Desulfovibrio.
OX   NCBI_TaxID=391774;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DP4;
RX   PubMed=19737303; DOI=10.1111/j.1462-2920.2009.01946.x;
RA   Walker C.B., Stolyar S., Chivian D., Pinel N., Gabster J.A., Dehal P.S.,
RA   He Z., Yang Z.K., Yen H.C., Zhou J., Wall J.D., Hazen T.C., Arkin A.P.,
RA   Stahl D.A.;
RT   "Contribution of mobile genetic elements to Desulfovibrio vulgaris genome
RT   plasticity.";
RL   Environ. Microbiol. 11:2244-2252(2009).
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; CP000527; ABM29180.1; -; Genomic_DNA.
DR   RefSeq; WP_011792696.1; NC_008751.1.
DR   AlphaFoldDB; A1VFG4; -.
DR   SMR; A1VFG4; -.
DR   EnsemblBacteria; ABM29180; ABM29180; Dvul_2164.
DR   KEGG; dvl:Dvul_2164; -.
DR   HOGENOM; CLU_050019_0_0_7; -.
DR   OMA; DYPGTMG; -.
DR   Proteomes; UP000009173; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Repressor; Stress response; Transcription; Transcription regulation.
FT   CHAIN           1..355
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_1000010406"
SQ   SEQUENCE   355 AA;  38564 MW;  0AFC31090A242A2B CRC64;
     MSALGSRETH VLTTIIESYI TSAAPVGSRT VSRRSGLALS PASMRNTMSD LTDMGFLEQP
     HTSAGRIPTP KAFRLYVDAL LRQSARRDEA PLHMVEALHG HEPEVGALLR RASNLVSEHA
     RQVSMVLAPG PAEARLRSLD FVPAGEGLVL AVLVLEGGMV RTRLVRDDTH FGSDELVRFG
     NYINAHYRGH TLSGIRNSIH HELSGGGAQL EAMCAQALAL GSLALDSIDD DRELYVNGTR
     NILDQAEFAE LGRMRELMDA LEERSRLLEL LDRTILEDDV HVTFYPDDVS GAAQRRAPDG
     LRGCSMVSAP YGGASPLGVI GVIGPVRMDY RKVLPLVGAV SRVLTQLLRE RFATG