HRCA_ENTFA
ID HRCA_ENTFA Reviewed; 347 AA.
AC Q835R9;
DT 26-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 103.
DE RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=EF_1306;
OS Enterococcus faecalis (strain ATCC 700802 / V583).
OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Enterococcaceae;
OC Enterococcus.
OX NCBI_TaxID=226185;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700802 / V583;
RX PubMed=12663927; DOI=10.1126/science.1080613;
RA Paulsen I.T., Banerjei L., Myers G.S.A., Nelson K.E., Seshadri R.,
RA Read T.D., Fouts D.E., Eisen J.A., Gill S.R., Heidelberg J.F., Tettelin H.,
RA Dodson R.J., Umayam L.A., Brinkac L.M., Beanan M.J., Daugherty S.C.,
RA DeBoy R.T., Durkin S.A., Kolonay J.F., Madupu R., Nelson W.C.,
RA Vamathevan J.J., Tran B., Upton J., Hansen T., Shetty J., Khouri H.M.,
RA Utterback T.R., Radune D., Ketchum K.A., Dougherty B.A., Fraser C.M.;
RT "Role of mobile DNA in the evolution of vancomycin-resistant Enterococcus
RT faecalis.";
RL Science 299:2071-2074(2003).
CC -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC dnaJ and groELS operons). Prevents heat-shock induction of these
CC operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC Rule:MF_00081}.
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DR EMBL; AE016830; AAO81098.1; -; Genomic_DNA.
DR RefSeq; NP_815028.1; NC_004668.1.
DR RefSeq; WP_002357828.1; NZ_KE136528.1.
DR AlphaFoldDB; Q835R9; -.
DR SMR; Q835R9; -.
DR STRING; 226185.EF_1306; -.
DR EnsemblBacteria; AAO81098; AAO81098; EF_1306.
DR GeneID; 60893689; -.
DR KEGG; efa:EF1306; -.
DR PATRIC; fig|226185.45.peg.2195; -.
DR eggNOG; COG1420; Bacteria.
DR HOGENOM; CLU_050019_1_0_9; -.
DR OMA; DYPGTMG; -.
DR Proteomes; UP000001415; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.10.10; -; 1.
DR Gene3D; 3.30.390.60; -; 1.
DR Gene3D; 3.30.450.40; -; 1.
DR HAMAP; MF_00081; HrcA; 1.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR002571; HrcA.
DR InterPro; IPR021153; HrcA_C.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR PANTHER; PTHR34824; PTHR34824; 1.
DR Pfam; PF01628; HrcA; 1.
DR PIRSF; PIRSF005485; HrcA; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR TIGRFAMs; TIGR00331; hrcA; 1.
PE 3: Inferred from homology;
KW Reference proteome; Repressor; Stress response; Transcription;
KW Transcription regulation.
FT CHAIN 1..347
FT /note="Heat-inducible transcription repressor HrcA"
FT /id="PRO_0000182478"
SQ SEQUENCE 347 AA; 39211 MW; 93CF135B05CD9994 CRC64;
MITERQQNIL RLIIQNYTNT GLPVGSKKLM EDGIASSSAT IRNDMKALEE YGLLAKTHSS
SGRIPSMAGY RYYVDHLLQP TQVEENELRR IRQSFGKEFH EINDIIRQSA EILSELTSYT
AFSLGPEVKE RKLTGFRMVP LNDRQVLAII VTDKGNVENQ VFAIPAAVSS QDLEKMTQII
NDKLVGQPLL TVYHRLRTEI PMILHRYFQT PEGMMNLFDE MLGHAFEEKV FVGGRMNLLD
FGIKQDIEQL KSVYSFMQNS DELTHLLNGS ATTENPIVFR IGSEIGNNLL EDMSMITATY
EVSGHGKGTI ALLGPTSMPY SKIFGLVDTF RHELASQLGD YYRFLGN