ID   HRCA_ERYLH              Reviewed;         346 AA.
AC   Q2NAJ6;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   07-FEB-2006, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=ELI_06015;
OS   Erythrobacter litoralis (strain HTCC2594).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Sphingomonadales;
OC   Erythrobacteraceae; Erythrobacter/Porphyrobacter group; Erythrobacter.
OX   NCBI_TaxID=314225;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HTCC2594;
RX   PubMed=19168610; DOI=10.1128/jb.00026-09;
RA   Oh H.M., Giovannoni S.J., Ferriera S., Johnson J., Cho J.C.;
RT   "Complete genome sequence of Erythrobacter litoralis HTCC2594.";
RL   J. Bacteriol. 191:2419-2420(2009).
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; CP000157; ABC63295.1; -; Genomic_DNA.
DR   RefSeq; WP_011414131.1; NC_007722.1.
DR   AlphaFoldDB; Q2NAJ6; -.
DR   SMR; Q2NAJ6; -.
DR   STRING; 314225.ELI_06015; -.
DR   PRIDE; Q2NAJ6; -.
DR   EnsemblBacteria; ABC63295; ABC63295; ELI_06015.
DR   KEGG; eli:ELI_06015; -.
DR   eggNOG; COG1420; Bacteria.
DR   HOGENOM; CLU_050019_0_0_5; -.
DR   OMA; DYPGTMG; -.
DR   OrthoDB; 1510750at2; -.
DR   Proteomes; UP000008808; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repressor; Stress response; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..346
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_1000010407"
SQ   SEQUENCE   346 AA;  36871 MW;  148CD109BD0C1C83 CRC64;
     MAVPPVTELT DRARAIFQLV VEGYLESGQP VGSKTLSQEQ SLDLSPASIR SVLADLESIG
     LLAAPHTSAG RMPTETGLRL FVDGMMQVAE PTRAEREAIA QRLKRSGPIE QALEATSSML
     SDLSGAAGMV MVPSREPRLA QISLVPLGQG KALAVLVGED GAIENRVIET GDTPAHVLEQ
     VSNFITARLA GRTLAEATAA MRKEIADGKS ALDTASQNLV ERGLAVWTED AAERPVLIVR
     GQANLLDESA LEDLDRVRSL LDDLENKQSV AELLETARDA EATRIFIGSE NRLFALSGSS
     VIASPYRDRE GKVVGVLGVI GPTRLNYARV VPMVDFTARS LGKLIG