ID   HRCA_FRUSA              Reviewed;         346 AA.
AC   Q8KML8;
DT   16-JUN-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   25-MAY-2022, entry version 67.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081};
OS   Fructilactobacillus sanfranciscensis (Lactobacillus sanfranciscensis).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Fructilactobacillus.
OX   NCBI_TaxID=1625;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 27651 / DSM 20451 / JCM 5668 / KCTC 3205 / NCIMB 702811 / NRRL
RC   B-3934 / L-12;
RA   Ehrmann M.A.;
RT   "Identification and characterization of the dnak operon of Lactobacillus
RT   sanfranciscensis.";
RL   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; AJ315380; CAC86403.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q8KML8; -.
DR   SMR; Q8KML8; -.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR005104; WHTH_HrcA_DNA-bd.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   Pfam; PF03444; HrcA_DNA-bdg; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Repressor; Stress response; Transcription; Transcription regulation.
FT   CHAIN           1..346
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_0000182491"
SQ   SEQUENCE   346 AA;  39345 MW;  C658647E3D835242 CRC64;
     MLTERQSMIL KYIIDDYSKT GVPIGSKALA EQLPIHVSSA TIRNEMAVLS HQNFIEKLHT
     SSGRVPSNQG YRYYIDNLAK PAKLDTKRLE YISEMLDGSF QQIDEIVRQS ADILSHLTDY
     TALTFSPELT TENTIKHLQL VNLGLNRMMV VIVMGNEQVE SQSFLVTNQY IDSQLSLATN
     LLNQQLVGKT AREVKQVFQS KILTELHTYL PDTKQFVRAI QAILSKIDDD HYFISGQMNM
     FEQNGKQDFS KIKSLYSMFN NDNGIDALLE KSSKPISVKI GAEFDNDWLK DYSIITGSYD
     LGNHGIGRIA LIGPMRMSYP NMLGVVDAFR HELKNRISGY YRSYDQ