ID   HRCA_FUSNN              Reviewed;         351 AA.
AC   Q8RH08;
DT   13-AUG-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   03-AUG-2022, entry version 104.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=FN0113;
OS   Fusobacterium nucleatum subsp. nucleatum (strain ATCC 25586 / DSM 15643 /
OS   BCRC 10681 / CIP 101130 / JCM 8532 / KCTC 2640 / LMG 13131 / VPI 4355).
OC   Bacteria; Fusobacteria; Fusobacteriales; Fusobacteriaceae; Fusobacterium.
OX   NCBI_TaxID=190304;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25586 / DSM 15643 / BCRC 10681 / CIP 101130 / JCM 8532 / KCTC
RC   2640 / LMG 13131 / VPI 4355;
RX   PubMed=11889109; DOI=10.1128/jb.184.7.2005-2018.2002;
RA   Kapatral V., Anderson I., Ivanova N., Reznik G., Los T., Lykidis A.,
RA   Bhattacharyya A., Bartman A., Gardner W., Grechkin G., Zhu L., Vasieva O.,
RA   Chu L., Kogan Y., Chaga O., Goltsman E., Bernal A., Larsen N., D'Souza M.,
RA   Walunas T., Pusch G., Haselkorn R., Fonstein M., Kyrpides N.C.,
RA   Overbeek R.;
RT   "Genome sequence and analysis of the oral bacterium Fusobacterium nucleatum
RT   strain ATCC 25586.";
RL   J. Bacteriol. 184:2005-2018(2002).
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; AE009951; AAL94322.1; -; Genomic_DNA.
DR   RefSeq; NP_603023.1; NC_003454.1.
DR   AlphaFoldDB; Q8RH08; -.
DR   SMR; Q8RH08; -.
DR   STRING; 190304.FN0113; -.
DR   EnsemblBacteria; AAL94322; AAL94322; FN0113.
DR   KEGG; fnu:FN0113; -.
DR   PATRIC; fig|190304.8.peg.700; -.
DR   eggNOG; COG1420; Bacteria.
DR   HOGENOM; CLU_050019_1_0_0; -.
DR   InParanoid; Q8RH08; -.
DR   OMA; DYPGTMG; -.
DR   BioCyc; FNUC190304:G1FZS-724-MON; -.
DR   Proteomes; UP000002521; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IBA:GO_Central.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repressor; Stress response; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..351
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_0000182479"
SQ   SEQUENCE   351 AA;  40306 MW;  BC5C344DFF4F9B2E CRC64;
     MSANKKVRGE IMGISEREKL VLNAIVDYYL TVGDTIGSRT LVKKYGIELS SATIRNVMAD
     LEDMGFIEKT HTSSGRIPTD MGYKYYLTEL LKVEKITQEE IENISNVYNR RVDELENILK
     KTSTLLSKLT NYAGIAVEPK PDNKKVSRVE LVYIDEYLVM AIIVMDDRRV KTKNIHLAYP
     ISKEEVEKKV DELNAKIRNN EIAINDIEKF FTESTDIVYE YDDEDELSKY FINNLPSMLK
     NENIAEVTDV IEFFNERKDI RELFEKLIEQ KAQENSKSNV NVILGDELGI KELEDFSFVY
     SIYDIGGAQG IIGVMGPKRM AYSKTMGLIN HVSREVNKLI NSMEKDKNKK V