ID   HRCA_GEOKA              Reviewed;         344 AA.
AC   Q5KWZ5;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-2005, sequence version 1.
DT   25-MAY-2022, entry version 86.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=GK2506;
OS   Geobacillus kaustophilus (strain HTA426).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Geobacillus;
OC   Geobacillus thermoleovorans group.
OX   NCBI_TaxID=235909;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HTA426;
RX   PubMed=15576355; DOI=10.1093/nar/gkh970;
RA   Takami H., Takaki Y., Chee G.-J., Nishi S., Shimamura S., Suzuki H.,
RA   Matsui S., Uchiyama I.;
RT   "Thermoadaptation trait revealed by the genome sequence of thermophilic
RT   Geobacillus kaustophilus.";
RL   Nucleic Acids Res. 32:6292-6303(2004).
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; BA000043; BAD76791.1; -; Genomic_DNA.
DR   RefSeq; WP_011231985.1; NC_006510.1.
DR   AlphaFoldDB; Q5KWZ5; -.
DR   SMR; Q5KWZ5; -.
DR   STRING; 235909.GK2506; -.
DR   EnsemblBacteria; BAD76791; BAD76791; GK2506.
DR   KEGG; gka:GK2506; -.
DR   PATRIC; fig|235909.7.peg.2683; -.
DR   eggNOG; COG1420; Bacteria.
DR   HOGENOM; CLU_050019_1_0_9; -.
DR   OMA; DYPGTMG; -.
DR   Proteomes; UP000001172; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repressor; Stress response; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..344
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_0000182480"
SQ   SEQUENCE   344 AA;  39017 MW;  F06EEE8DE390A8DB CRC64;
     MLTDRQLLIL QVIIDDFIRS GQPVGSRTLS KKHQIAFSSA TIRNEMADLE ELGYIEKTHI
     SSGRVPSEKG YRYYVDHLLP PQRLTRADIQ KIRSVFAERI YELEKLMQKS AQILSELTNY
     TSIALGPTFK ESKLKQMQIV PLNEQTAVAI VVTDTGHVEN RVVTIPSSMD AGDLEKMVNI
     FNERLNGVPL IDLKEKMETE VADVLRRHIR NYDSVLNTLI ETLDAPEEEK VFFAGKANML
     NQPEFSDIQK VRPLLDIIEQ EKDIYRLLRK QTQKGVRVSI GHENELRGME NCSLITATYS
     VGDEPLGAIA ILGPTRMEYS RVITVLNRVA SDLSAALAKW YQSQ