ID   HRCA_GEOSE              Reviewed;         344 AA.
AC   Q45550;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   15-JUL-1998, sequence version 3.
DT   25-MAY-2022, entry version 86.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081};
OS   Geobacillus stearothermophilus (Bacillus stearothermophilus).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Geobacillus.
OX   NCBI_TaxID=1422;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=NUB36;
RX   PubMed=9266682; DOI=10.1016/s0378-1119(97)00000-0;
RA   Mogk A., Schumann W.;
RT   "Cloning and sequencing of the hrcA gene of Bacillus stearothermophilus.";
RL   Gene 194:133-136(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 292-344.
RC   STRAIN=NUB36;
RX   PubMed=8621094; DOI=10.1016/0378-1119(95)00859-4;
RA   Herbort M., Schoen U., Lang J., Schumann W.;
RT   "Cloning and sequencing of the dnaK operon of Bacillus
RT   stearothermophilus.";
RL   Gene 170:81-84(1996).
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAA70594.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; Y09446; CAA70594.1; ALT_INIT; Genomic_DNA.
DR   EMBL; X90709; CAA62237.1; -; Genomic_DNA.
DR   PIR; PC4165; PC4165.
DR   AlphaFoldDB; Q45550; -.
DR   SMR; Q45550; -.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Repressor; Stress response; Transcription; Transcription regulation.
FT   CHAIN           1..344
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_0000182448"
SQ   SEQUENCE   344 AA;  39323 MW;  024FF713BF62C08F CRC64;
     MLTERQLLIL QVIIDDFIRS GQPVGSRTLS KKHEIALSSA TIRNEMADLE ELGYIEKTHV
     SSGRVPSEKG YRYYVDHLLS PQRLTKDDIQ KIKSIFAERI YELEKVVQKS AQILSDLTNY
     TSIALGPAVK ENKLKRIQII PLNQQTAVAI IVTDTGHVEN HVITVPASVN PSDLEKMVNI
     FNERLIGVPL VDLKDKIYKK VADVLRKHIR NYDSMLQTIV ETLDIPQEEK MFFAGKTNML
     NQPEFNDIQK IRPLMKMIEQ EKDFYRLLRK HNRKGIQVTI GRENQLSEME NCSLITATYS
     IGDEQLGTIA ILGPTRMEYS RVITILNRVA SDLSIALTKW YQNG