ID   HRCA_GEOSL              Reviewed;         342 AA.
AC   Q74H61;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 98.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=GSU0031;
OS   Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA).
OC   Bacteria; Proteobacteria; Deltaproteobacteria; Desulfuromonadales;
OC   Geobacteraceae; Geobacter.
OX   NCBI_TaxID=243231;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51573 / DSM 12127 / PCA;
RX   PubMed=14671304; DOI=10.1126/science.1088727;
RA   Methe B.A., Nelson K.E., Eisen J.A., Paulsen I.T., Nelson W.C.,
RA   Heidelberg J.F., Wu D., Wu M., Ward N.L., Beanan M.J., Dodson R.J.,
RA   Madupu R., Brinkac L.M., Daugherty S.C., DeBoy R.T., Durkin A.S.,
RA   Gwinn M.L., Kolonay J.F., Sullivan S.A., Haft D.H., Selengut J.,
RA   Davidsen T.M., Zafar N., White O., Tran B., Romero C., Forberger H.A.,
RA   Weidman J.F., Khouri H.M., Feldblyum T.V., Utterback T.R., Van Aken S.E.,
RA   Lovley D.R., Fraser C.M.;
RT   "Genome of Geobacter sulfurreducens: metal reduction in subsurface
RT   environments.";
RL   Science 302:1967-1969(2003).
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; AE017180; AAR33366.1; -; Genomic_DNA.
DR   RefSeq; NP_951093.1; NC_002939.5.
DR   RefSeq; WP_010940709.1; NC_002939.5.
DR   AlphaFoldDB; Q74H61; -.
DR   SMR; Q74H61; -.
DR   STRING; 243231.GSU0031; -.
DR   DNASU; 2685607; -.
DR   EnsemblBacteria; AAR33366; AAR33366; GSU0031.
DR   KEGG; gsu:GSU0031; -.
DR   PATRIC; fig|243231.5.peg.32; -.
DR   eggNOG; COG1420; Bacteria.
DR   HOGENOM; CLU_050019_1_0_7; -.
DR   InParanoid; Q74H61; -.
DR   OMA; DYPGTMG; -.
DR   Proteomes; UP000000577; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IBA:GO_Central.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR005104; WHTH_HrcA_DNA-bd.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   Pfam; PF03444; HrcA_DNA-bdg; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repressor; Stress response; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..342
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_0000182481"
SQ   SEQUENCE   342 AA;  38374 MW;  4D124A13FCD7D24D CRC64;
     MTDISERNKL ILEAIIEDYI TTAEPVGSRA VTKRHGLTLS PATVRNVMAD LEEMGYLVSP
     HTSAGRVPTD KAYRLYVDSL LAVRRIDKVE RERIRKRYAE AGRDIGAVLH ETSRLLSSVS
     HYTGIVLAPR FSATIFRHIE FVKLGGRRIL VILVADNGTV QNRLIESDEE FSSEELIRMS
     NYLNELLVGV PVGQVRTRIL EEMRNEKVLY DKLLARALQL SEQSLNDDGA QIFIEGQTNI
     LEQPEFADSR RMRDLFRAFE EKNQLVGLLD RCLNAQGVQI FIGAETHLSQ MEGLSIITST
     YLTGKNTLGV LGVIGPTRMG YAKVIPIVDY TAKLVSRLLE GE