ID   HRCA_GEOSW              Reviewed;         344 AA.
AC   C5D4U3;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   25-MAY-2022, entry version 70.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=GWCH70_2439;
OS   Geobacillus sp. (strain WCH70).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Geobacillus;
OC   unclassified Geobacillus.
OX   NCBI_TaxID=471223;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WCH70;
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA   Bruce D., Goodwin L., Pitluck S., Chertkov O., Brettin T., Detter J.C.,
RA   Han C., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N.,
RA   Brumm P., Mead D.A., Richardson P.;
RT   "Complete sequence of chromosome of Geopacillus sp. WCH70.";
RL   Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; CP001638; ACS25135.1; -; Genomic_DNA.
DR   RefSeq; WP_015864549.1; NC_012793.1.
DR   AlphaFoldDB; C5D4U3; -.
DR   SMR; C5D4U3; -.
DR   STRING; 471223.GWCH70_2439; -.
DR   EnsemblBacteria; ACS25135; ACS25135; GWCH70_2439.
DR   KEGG; gwc:GWCH70_2439; -.
DR   eggNOG; COG1420; Bacteria.
DR   HOGENOM; CLU_050019_1_0_9; -.
DR   OMA; DYPGTMG; -.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Repressor; Stress response; Transcription; Transcription regulation.
FT   CHAIN           1..344
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_1000202551"
SQ   SEQUENCE   344 AA;  39123 MW;  44DA151CD5CA49F7 CRC64;
     MLTDRQLLIL QVIIDDFIRS GQPVGSRTLS KKHEIALSSA TIRNEMADLE ELGYIEKTHV
     SSGRVPSEKG YRYYVDHLLS PQRLTQEDIQ KIKSIFAERI YELEKVVQKS AQILSDLTNY
     TSIALGPAVK ENKLKRIQII PLNQQTAVAI IVTDTGHVEN HVITVPASVN PSDLEKMVNI
     LNERLIGVPL VDLKDKIYKE VADVLRTHIH NYDSMLKTIV DTLDIPQEEK MFFAGTTNML
     NQPEFSDIQK VRSLMKMIEQ EKDFYRLLRK HNRKGIQVTI GRENQLSGME NCSLITATYS
     IGNEQLGTIA ILGPTRMEYS RVITILNRVA SDLSTALTKW YQNN