ID   HRCA_GLOVI              Reviewed;         360 AA.
AC   Q7NIB2;
DT   26-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-2003, sequence version 1.
DT   25-MAY-2022, entry version 100.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=gll2271;
OS   Gloeobacter violaceus (strain ATCC 29082 / PCC 7421).
OC   Bacteria; Cyanobacteria; Gloeobacteria; Gloeobacterales; Gloeobacteraceae;
OC   Gloeobacter.
OX   NCBI_TaxID=251221;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29082 / PCC 7421;
RX   PubMed=14621292; DOI=10.1093/dnares/10.4.137;
RA   Nakamura Y., Kaneko T., Sato S., Mimuro M., Miyashita H., Tsuchiya T.,
RA   Sasamoto S., Watanabe A., Kawashima K., Kishida Y., Kiyokawa C., Kohara M.,
RA   Matsumoto M., Matsuno A., Nakazaki N., Shimpo S., Takeuchi C., Yamada M.,
RA   Tabata S.;
RT   "Complete genome structure of Gloeobacter violaceus PCC 7421, a
RT   cyanobacterium that lacks thylakoids.";
RL   DNA Res. 10:137-145(2003).
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; BA000045; BAC90212.1; -; Genomic_DNA.
DR   RefSeq; NP_925217.1; NC_005125.1.
DR   RefSeq; WP_011142268.1; NC_005125.1.
DR   AlphaFoldDB; Q7NIB2; -.
DR   SMR; Q7NIB2; -.
DR   STRING; 251221.35212839; -.
DR   EnsemblBacteria; BAC90212; BAC90212; BAC90212.
DR   KEGG; gvi:gll2271; -.
DR   PATRIC; fig|251221.4.peg.2306; -.
DR   eggNOG; COG1420; Bacteria.
DR   HOGENOM; CLU_050019_1_0_3; -.
DR   InParanoid; Q7NIB2; -.
DR   OMA; DYPGTMG; -.
DR   OrthoDB; 1510750at2; -.
DR   PhylomeDB; Q7NIB2; -.
DR   Proteomes; UP000000557; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IBA:GO_Central.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repressor; Stress response; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..360
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_0000182482"
SQ   SEQUENCE   360 AA;  39891 MW;  1EE3BE759D603D26 CRC64;
     MSSFSFESSA RLPLNPRFKQ ILHATVKSYI DTAEPVGSKM LTQQYNFGLS SATIRNAMAV
     LESWGLLFQP HTSAGRIPSD SGYRVYVDEL ISPPTELIQQ MRAALAENLG ERQDLESLLQ
     GATRLLATLS GCVALITAPQ SVFVSVRHLQ IVHIGEGRAL VIVVTDALQT RSFLLDLPQP
     EMAEQLETLN NFLNLQLQNR RLDDLNAAAV EAMGGEFHWY TDFLRGLIAL LQRVLQPPTG
     QLYVSGVGEI LKQPEFAEPE RIQAIVQLLE VERERLGPLI SPTQRHSRQI VVRIGAENPL
     GPMQFCSLVS STYYLNEVPV GSVGVLGPTR LPYDRAIASV QAASDHLCQV MQAEDEPHRW