ID   HRCA_GLUOX              Reviewed;         356 AA.
AC   Q5FRF2;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2005, sequence version 1.
DT   25-MAY-2022, entry version 90.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=GOX1283;
OS   Gluconobacter oxydans (strain 621H) (Gluconobacter suboxydans).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhodospirillales;
OC   Acetobacteraceae; Gluconobacter.
OX   NCBI_TaxID=290633;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=621H;
RX   PubMed=15665824; DOI=10.1038/nbt1062;
RA   Prust C., Hoffmeister M., Liesegang H., Wiezer A., Fricke W.F.,
RA   Ehrenreich A., Gottschalk G., Deppenmeier U.;
RT   "Complete genome sequence of the acetic acid bacterium Gluconobacter
RT   oxydans.";
RL   Nat. Biotechnol. 23:195-200(2005).
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; CP000009; AAW61044.1; -; Genomic_DNA.
DR   RefSeq; WP_011252836.1; NZ_LT900338.1.
DR   AlphaFoldDB; Q5FRF2; -.
DR   SMR; Q5FRF2; -.
DR   STRING; 290633.GOX1283; -.
DR   EnsemblBacteria; AAW61044; AAW61044; GOX1283.
DR   KEGG; gox:GOX1283; -.
DR   eggNOG; COG1420; Bacteria.
DR   HOGENOM; CLU_050019_0_0_5; -.
DR   OMA; DYPGTMG; -.
DR   Proteomes; UP000006375; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repressor; Stress response; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..356
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_1000010410"
SQ   SEQUENCE   356 AA;  38318 MW;  2BD13A232590D22C CRC64;
     MMRPQPPLFR PSIPMPHGLG DREAAILREI VEEYVETGEP IGSQTLAQRL QPSLSPATIR
     NVMAELARAG LLFSPHVSAG RLPTEKGVRL FVDGLLQFSS LTEEDRASID SRLDIHGRSY
     QDILSEASSL LSGLSSAAGL VLAPKSDATL KHIEFVALGP GRVLVILVGS DGQVENRIIE
     TPPGVPPSAL VEAGNYLNSR LGDLTLGNLR ERVRAEMDAS RHELDALTAS VIESGLATWD
     ADGGTLFVKG QGKLLADITE IERLTTIRML FDHLETQETM LQLLQLADAS EGVRIYIGRE
     SGMFGMSGVS MIVAPARNEA QKIVGAIGVI GPTRLNYGRI VPVVDYTARM VGRLLG