ID   HRCA_HELMI              Reviewed;         347 AA.
AC   B0TAD4;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 1.
DT   25-MAY-2022, entry version 79.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=Helmi_23590;
GN   ORFNames=HM1_2434;
OS   Heliobacterium modesticaldum (strain ATCC 51547 / Ice1).
OC   Bacteria; Firmicutes; Clostridia; Eubacteriales; Heliobacteriaceae;
OC   Heliomicrobium.
OX   NCBI_TaxID=498761;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51547 / Ice1;
RX   PubMed=18441057; DOI=10.1128/jb.00299-08;
RA   Sattley W.M., Madigan M.T., Swingley W.D., Cheung P.C., Clocksin K.M.,
RA   Conrad A.L., Dejesa L.C., Honchak B.M., Jung D.O., Karbach L.E.,
RA   Kurdoglu A., Lahiri S., Mastrian S.D., Page L.E., Taylor H.L., Wang Z.T.,
RA   Raymond J., Chen M., Blankenship R.E., Touchman J.W.;
RT   "The genome of Heliobacterium modesticaldum, a phototrophic representative
RT   of the Firmicutes containing the simplest photosynthetic apparatus.";
RL   J. Bacteriol. 190:4687-4696(2008).
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; CP000930; ABZ84984.1; -; Genomic_DNA.
DR   RefSeq; WP_012283481.1; NC_010337.2.
DR   AlphaFoldDB; B0TAD4; -.
DR   SMR; B0TAD4; -.
DR   STRING; 498761.HM1_2434; -.
DR   PRIDE; B0TAD4; -.
DR   EnsemblBacteria; ABZ84984; ABZ84984; HM1_2434.
DR   KEGG; hmo:HM1_2434; -.
DR   eggNOG; COG1420; Bacteria.
DR   HOGENOM; CLU_050019_1_0_9; -.
DR   OMA; DYPGTMG; -.
DR   OrthoDB; 1510750at2; -.
DR   Proteomes; UP000008550; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR005104; WHTH_HrcA_DNA-bd.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   Pfam; PF03444; HrcA_DNA-bdg; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repressor; Stress response; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..347
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_1000092811"
SQ   SEQUENCE   347 AA;  39078 MW;  6BFE2D875C05C4C9 CRC64;
     MQMNDRKQKV LWAIIQDYVS TAEPVGSRTI ARKYDLGVSP ATIRNEMSDL EELGLIEQPY
     TSSGRIPSDY GYRYFVDCLM ERETLNPEEL RKVKRAMSER LQEVNSIMQQ TTNLLAELTN
     YTAVALGPQV GKTTFQQIHF FPVMPTKAVA VVVTSAGVME NKILDIPESM TPEDLQKVSV
     MINERLQGLT MAQVRASLCM ELNEALKKQK QVLSRSLELI DEALHGDSGE RFFLAGMMNI
     FKQPEFKDVE KLQNLLGILE QHQTMRELMH DHPEPGIHIK IGAENRHEGV RNCSMVTASY
     HLDGEVLGVI GLIGPTRMEY SKAVAVVEEL TEQLSAVLKK CLIVRGI