ID   HRCA_HELPJ              Reviewed;         266 AA.
AC   Q9ZMW2;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   25-MAY-2022, entry version 112.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=jhp_0103;
OS   Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99).
OC   Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC   Helicobacteraceae; Helicobacter.
OX   NCBI_TaxID=85963;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=J99 / ATCC 700824;
RX   PubMed=9923682; DOI=10.1038/16495;
RA   Alm R.A., Ling L.-S.L., Moir D.T., King B.L., Brown E.D., Doig P.C.,
RA   Smith D.R., Noonan B., Guild B.C., deJonge B.L., Carmel G., Tummino P.J.,
RA   Caruso A., Uria-Nickelsen M., Mills D.M., Ives C., Gibson R., Merberg D.,
RA   Mills S.D., Jiang Q., Taylor D.E., Vovis G.F., Trust T.J.;
RT   "Genomic sequence comparison of two unrelated isolates of the human gastric
RT   pathogen Helicobacter pylori.";
RL   Nature 397:176-180(1999).
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; AE001439; AAD05682.1; -; Genomic_DNA.
DR   PIR; A71974; A71974.
DR   RefSeq; WP_000919598.1; NZ_CP011330.1.
DR   AlphaFoldDB; Q9ZMW2; -.
DR   STRING; 85963.jhp_0103; -.
DR   EnsemblBacteria; AAD05682; AAD05682; jhp_0103.
DR   KEGG; hpj:jhp_0103; -.
DR   PATRIC; fig|85963.30.peg.925; -.
DR   eggNOG; COG1420; Bacteria.
DR   OMA; LCVGKLE; -.
DR   Proteomes; UP000000804; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
PE   3: Inferred from homology;
KW   Repressor; Stress response; Transcription; Transcription regulation.
FT   CHAIN           1..266
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_0000182484"
SQ   SEQUENCE   266 AA;  30790 MW;  D6E10D01C411C686 CRC64;
     MLKRIKVGSD LNKKESLLDA FVKTYLQTLE PISSKRLKEL ANLKVSCATI RNYFQILSKE
     GMLHQAHSSG ARLPTFKAFE NYWHKSLRFE VLKVNEKRLK SASENFGLFT LLKKPSLERL
     ERVIECEKRF LILDFLAFSC AVGYSVKMEK FLLELVGRSV KEVRLIAASV NALSLARQLE
     RLEYSSAQIT RFNLMGLKTL LNSPLFFDIL EGKVLERFKK GLHFIEPDCM LVTRPIEFQN
     ERMQLLCVGK LECDYEGFFQ TISKEE