ID   HRCA_HELPY              Reviewed;         266 AA.
AC   O24933;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2000, sequence version 2.
DT   25-MAY-2022, entry version 106.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=HP_0111;
OS   Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori).
OC   Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC   Helicobacteraceae; Helicobacter.
OX   NCBI_TaxID=85962;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700392 / 26695;
RX   PubMed=9252185; DOI=10.1038/41483;
RA   Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G.,
RA   Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A.,
RA   Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N.,
RA   Loftus B.J., Richardson D.L., Dodson R.J., Khalak H.G., Glodek A.,
RA   McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E.,
RA   Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D.,
RA   Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S.,
RA   Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C.;
RT   "The complete genome sequence of the gastric pathogen Helicobacter
RT   pylori.";
RL   Nature 388:539-547(1997).
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAD07182.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AE000511; AAD07182.1; ALT_INIT; Genomic_DNA.
DR   PIR; G64533; G64533.
DR   RefSeq; NP_206911.1; NC_000915.1.
DR   AlphaFoldDB; O24933; -.
DR   IntAct; O24933; 1.
DR   MINT; O24933; -.
DR   STRING; 85962.C694_00550; -.
DR   PaxDb; O24933; -.
DR   EnsemblBacteria; AAD07182; AAD07182; HP_0111.
DR   KEGG; hpy:HP_0111; -.
DR   PATRIC; fig|85962.8.peg.118; -.
DR   eggNOG; COG1420; Bacteria.
DR   OMA; LCVGKLE; -.
DR   Proteomes; UP000000429; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IBA:GO_Central.
DR   Gene3D; 1.10.10.10; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repressor; Stress response; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..266
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_0000182483"
SQ   SEQUENCE   266 AA;  30795 MW;  F1A3F7001FF41F03 CRC64;
     MLRRIKVGSN LNKKESLLDA FVKTYLQILE PISSKRLKEL ADLKISCATI RNYFQILSKE
     GMLYQAHSSG ARLPTFKAFE NYWQKSLRFE TLKVNEKRLK SASENFGLFT LLKKPSLERL
     ERVIECEKRF LILDFLAFSC ALGYSVKMEK FLLELVGRSV KEVRSIAASF NALSLARQLE
     RLEYSNTQIT RFNLMGLKTL LNSPLFFDIL GGKVLERLSK GLHFIEPDCM LVTRPVEFQN
     KRMQLLCVGK LECDYEGFFQ TISEEE