ID   HRCA_HERA2              Reviewed;         354 AA.
AC   A9AUH0;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   15-JAN-2008, sequence version 1.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=Haur_0438;
OS   Herpetosiphon aurantiacus (strain ATCC 23779 / DSM 785 / 114-95).
OC   Bacteria; Chloroflexi; Chloroflexia; Herpetosiphonales; Herpetosiphonaceae;
OC   Herpetosiphon.
OX   NCBI_TaxID=316274;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 23779 / DSM 785 / 114-95;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA   Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Detter J.C., Han C.,
RA   Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E.,
RA   Bryant D.A., Richardson P.;
RT   "Complete sequence of chromosome of Herpetosiphon aurantiacus ATCC 23779.";
RL   Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; CP000875; ABX03089.1; -; Genomic_DNA.
DR   AlphaFoldDB; A9AUH0; -.
DR   SMR; A9AUH0; -.
DR   STRING; 316274.Haur_0438; -.
DR   EnsemblBacteria; ABX03089; ABX03089; Haur_0438.
DR   KEGG; hau:Haur_0438; -.
DR   eggNOG; COG1420; Bacteria.
DR   HOGENOM; CLU_050019_0_0_0; -.
DR   OMA; DYPGTMG; -.
DR   Proteomes; UP000000787; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR013196; HTH_11.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   Pfam; PF08279; HTH_11; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repressor; Stress response; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..354
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_1000092812"
SQ   SEQUENCE   354 AA;  39218 MW;  200BD5702E1C95E6 CRC64;
     MHLELNERRR RVLKAVIQQY IDTATPVASQ DLARSLGVSS ATVRNEMAAL EDAGLLTHLH
     TSAGRLPTDA GYRFFVENLM DRAALSTQEQ RMIQHQFYQI RSELNQWIHL AAAVLARTAQ
     TAAVVTPPRA YESRFKHIEL ISINDALVLL VLVLHEGSVK QQTLPADPNT TQEQLSRIAG
     RINELCHEAS AKAIANIAHN QSTNQPPLSS FEVLVIESVA RAMQQFEEHV NELIHHDGLL
     EMLHQPEFGQ VTRVREVLSI LEGGTMLESL IPQALASDGV QVIIGGEHSR DELRDYSVIL
     SRYGVNGDVA GVVGVLGPRR MAYPRSISSV RYIAGVMSDL MGDLYGERKI EPSE