ID   HRCA_KOCRD              Reviewed;         337 AA.
AC   B2GHU5;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   10-JUN-2008, sequence version 1.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=KRH_13010;
OS   Kocuria rhizophila (strain ATCC 9341 / DSM 348 / NBRC 103217 / DC2201).
OC   Bacteria; Actinobacteria; Micrococcales; Micrococcaceae; Kocuria.
OX   NCBI_TaxID=378753;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 9341 / DSM 348 / NBRC 103217 / DC2201;
RX   PubMed=18408034; DOI=10.1128/jb.01853-07;
RA   Takarada H., Sekine M., Kosugi H., Matsuo Y., Fujisawa T., Omata S.,
RA   Kishi E., Shimizu A., Tsukatani N., Tanikawa S., Fujita N., Harayama S.;
RT   "Complete genome sequence of the soil actinomycete Kocuria rhizophila.";
RL   J. Bacteriol. 190:4139-4146(2008).
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; AP009152; BAG29648.1; -; Genomic_DNA.
DR   RefSeq; WP_012398369.1; NC_010617.1.
DR   AlphaFoldDB; B2GHU5; -.
DR   SMR; B2GHU5; -.
DR   STRING; 378753.KRH_13010; -.
DR   EnsemblBacteria; BAG29648; BAG29648; KRH_13010.
DR   KEGG; krh:KRH_13010; -.
DR   eggNOG; COG1420; Bacteria.
DR   HOGENOM; CLU_050019_2_0_11; -.
DR   OMA; DYPGTMG; -.
DR   OrthoDB; 1510750at2; -.
DR   Proteomes; UP000008838; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repressor; Stress response; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..337
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_1000092813"
SQ   SEQUENCE   337 AA;  36288 MW;  E69A275A5774EA1B CRC64;
     MENPRRVQIL RAIVEDYVHS REPVGSKALV ERHRLPVSSA TVRNDMAALE EAGLIVAPHT
     SSGRIPTDRG YRVFVDQIAA LQPLTGAQRR AIQVFLEGAH DLDDVMERTV RLLAQLTHQA
     AVIQYPVRAG ITVRHVELVD VGAGTVLVIL IPTSGRVAQR AVELAEPLDE VQLLELRARV
     LARVLGSTLE TVPGRVAGLA EELPEALRHA GDRVSEALAV LAAASDEHRL VMAGTANLAR
     FSGDFPQSIS PVLEALEEQV TMLRLLSAMQ QDERGVAVRI GSEECDDPLA EASVVATGYG
     PHAASKVGVV GPTRMDYPTT MAAVRAVARY LSRNLGD