ID   HRCA_LACAC              Reviewed;         349 AA.
AC   Q84BU6; Q5FJP2;
DT   31-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=LBA1249;
OS   Lactobacillus acidophilus (strain ATCC 700396 / NCK56 / N2 / NCFM).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Lactobacillus.
OX   NCBI_TaxID=272621;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=SBT2062;
RA   Aoyama K., Uenishi H., Nakajima H.;
RT   "Characterization of Lactobacillus acidophilus dnaK.";
RL   Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700396 / NCK56 / N2 / NCFM;
RX   PubMed=15671160; DOI=10.1073/pnas.0409188102;
RA   Altermann E., Russell W.M., Azcarate-Peril M.A., Barrangou R., Buck B.L.,
RA   McAuliffe O., Souther N., Dobson A., Duong T., Callanan M., Lick S.,
RA   Hamrick A., Cano R., Klaenhammer T.R.;
RT   "Complete genome sequence of the probiotic lactic acid bacterium
RT   Lactobacillus acidophilus NCFM.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:3906-3912(2005).
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; AB059359; BAC66858.1; -; Genomic_DNA.
DR   EMBL; CP000033; AAV43082.1; -; Genomic_DNA.
DR   RefSeq; WP_003547794.1; NC_006814.3.
DR   RefSeq; YP_194113.1; NC_006814.3.
DR   AlphaFoldDB; Q84BU6; -.
DR   SMR; Q84BU6; -.
DR   STRING; 272621.LBA1249; -.
DR   PRIDE; Q84BU6; -.
DR   EnsemblBacteria; AAV43082; AAV43082; LBA1249.
DR   GeneID; 56942840; -.
DR   KEGG; lac:LBA1249; -.
DR   PATRIC; fig|272621.13.peg.1184; -.
DR   eggNOG; COG1420; Bacteria.
DR   HOGENOM; CLU_050019_1_0_9; -.
DR   OMA; DYPGTMG; -.
DR   BioCyc; LACI272621:G1G49-1232-MON; -.
DR   Proteomes; UP000006381; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR005104; WHTH_HrcA_DNA-bd.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   Pfam; PF03444; HrcA_DNA-bdg; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repressor; Stress response; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..349
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_0000182485"
SQ   SEQUENCE   349 AA;  39180 MW;  62DD0BD413CF646C CRC64;
     MLTERQELIL KTIIMDFTQT HEPVGSKTVM NQLPIKVSSA TIRNEMAVLE DQGLIEKTHS
     SSGRIPSSEG YRYYLDNLVE PLKLPESVYN TIGSQLDRPF HQVNEIVQEA ARILSDLTNY
     TAFAEGPEKR DVKVTGFRIV PLSSRQVMAI LVTSDGNVQN QVYALPHNIY GEEIEKAVHM
     INDQLVGKSL NEINVSLLSE LAKSELGGEH VTELLSLVED VLKDAASEQM YVDGQINLLN
     NTSEHNVKDI RSLYELIDHD NLFSNLMDSK ADSKDKNYPI KVKLGSELPN DLLKNYSLLT
     AEYNVGSHGK GTIALLGPTN MPYSQMIGLL EYFRNELAKK LLDYYGKFQ