ID   HRCA_LACCB              Reviewed;         348 AA.
AC   B3WEQ9;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   02-SEP-2008, sequence version 1.
DT   25-MAY-2022, entry version 79.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=LCABL_17800;
OS   Lacticaseibacillus casei (strain BL23) (Lactobacillus casei).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Lacticaseibacillus.
OX   NCBI_TaxID=543734;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BL23;
RA   Maze A., Boel G., Bourand A., Loux V., Gibrat J.F., Zuniga M., Hartke A.,
RA   Deutscher J.;
RT   "Lactobacillus casei BL23 complete genome sequence.";
RL   Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; FM177140; CAQ66860.1; -; Genomic_DNA.
DR   RefSeq; WP_012491635.1; NC_010999.1.
DR   AlphaFoldDB; B3WEQ9; -.
DR   SMR; B3WEQ9; -.
DR   KEGG; lcb:LCABL_17800; -.
DR   HOGENOM; CLU_050019_1_0_9; -.
DR   OMA; DYPGTMG; -.
DR   OrthoDB; 1510750at2; -.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR013196; HTH_11.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   Pfam; PF08279; HTH_11; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Repressor; Stress response; Transcription; Transcription regulation.
FT   CHAIN           1..348
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_1000092814"
SQ   SEQUENCE   348 AA;  38444 MW;  79A67B7E260F0110 CRC64;
     MLTKRQLLVL KEIIRLFTES GQPVGSKTLM QELPVHVSSA TIRNDMAALE DAGLITKTHS
     SSGRVPSTQG YRYYLDHLVE PVRVSRHDLA TIKQELGQRY SKMDEIVAQS VQILSNLTSY
     TAISLGPEVN NIKLTGFRLV PLGNHQVMAI LVTNNGNVEN QVFTVPPSIS SDELEKAIRI
     VNDQLVGLPL VQVAQRLRTD VPSMLMQYLT SPDGFLDIFG NVLKSAASER FYVGGRLNLM
     DYLGDSDIHE LKKIMSLIDA DHGDLTELLG GPIRQTPVQV RLGPELKPID LANLSLITAS
     YDVGGHGTGM IALLGPTQMP YSKMIGLLDV FREELAKRLT DYYANFDQ