ID   HRCA_LACJO              Reviewed;         352 AA.
AC   Q74IT4;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 109.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=LJ_1481;
OS   Lactobacillus johnsonii (strain CNCM I-12250 / La1 / NCC 533).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Lactobacillus.
OX   NCBI_TaxID=257314;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CNCM I-1225 / La1 / NCC 533;
RX   PubMed=14983040; DOI=10.1073/pnas.0307327101;
RA   Pridmore R.D., Berger B., Desiere F., Vilanova D., Barretto C.,
RA   Pittet A.-C., Zwahlen M.-C., Rouvet M., Altermann E., Barrangou R.,
RA   Mollet B., Mercenier A., Klaenhammer T., Arigoni F., Schell M.A.;
RT   "The genome sequence of the probiotic intestinal bacterium Lactobacillus
RT   johnsonii NCC 533.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:2512-2517(2004).
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; AE017198; AAS09249.1; -; Genomic_DNA.
DR   RefSeq; WP_011162232.1; NC_005362.1.
DR   AlphaFoldDB; Q74IT4; -.
DR   SMR; Q74IT4; -.
DR   STRING; 257314.LJ_1481; -.
DR   EnsemblBacteria; AAS09249; AAS09249; LJ_1481.
DR   KEGG; ljo:LJ_1481; -.
DR   PATRIC; fig|257314.6.peg.1298; -.
DR   eggNOG; COG1420; Bacteria.
DR   HOGENOM; CLU_050019_1_0_9; -.
DR   OMA; DYPGTMG; -.
DR   Proteomes; UP000000581; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repressor; Stress response; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..352
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_0000182486"
SQ   SEQUENCE   352 AA;  39364 MW;  728F020719CA987E CRC64;
     MLTERQELIL KTIIMDFTQT HEPVGSKTVM NQLPVKVSSA TVRNEMAVLE EKGLLEKTHS
     SSGRIPSTAG YRYYLDHLIN PVKIPTSVYN QIVYQLDRPF QQVNEIVQEA AKILSDLTNY
     TAFAAGPETH SVKVTGFRIV PLSSHQVMAI LVTDDGNVKN QIYTLPHHTN GEEIEKAVRL
     INDQLVGKSL SSINEVLLKR IADHLIARGS APEILDLLQD VIKDAASEQM YVDGQINLLS
     NYENDDLTKI KSLYKLIDQN DALSSLIGFN PEDELKNDSS SKVQVKLGSE LPSDLLENYS
     LLTAQYSVGK YGKGTIALLG PTNMPYSQMI GLLEYFRNEL AKKLLDYYGR FK