ID   HRCA_LACLA              Reviewed;         347 AA.
AC   Q9CGZ0;
DT   27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT   27-APR-2001, sequence version 1.
DT   25-MAY-2022, entry version 110.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=LL0952;
GN   ORFNames=L0212;
OS   Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Lactococcus.
OX   NCBI_TaxID=272623;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IL1403;
RX   PubMed=11337471; DOI=10.1101/gr.gr-1697r;
RA   Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J.,
RA   Ehrlich S.D., Sorokin A.;
RT   "The complete genome sequence of the lactic acid bacterium Lactococcus
RT   lactis ssp. lactis IL1403.";
RL   Genome Res. 11:731-753(2001).
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; AE005176; AAK05050.1; -; Genomic_DNA.
DR   PIR; H86743; H86743.
DR   RefSeq; NP_267108.1; NC_002662.1.
DR   RefSeq; WP_010905650.1; NC_002662.1.
DR   AlphaFoldDB; Q9CGZ0; -.
DR   SMR; Q9CGZ0; -.
DR   STRING; 272623.L0212; -.
DR   PaxDb; Q9CGZ0; -.
DR   EnsemblBacteria; AAK05050; AAK05050; L0212.
DR   GeneID; 60355482; -.
DR   KEGG; lla:L0212; -.
DR   PATRIC; fig|272623.7.peg.1019; -.
DR   eggNOG; COG1420; Bacteria.
DR   HOGENOM; CLU_050019_1_0_9; -.
DR   OMA; DYPGTMG; -.
DR   Proteomes; UP000002196; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR005104; WHTH_HrcA_DNA-bd.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   Pfam; PF03444; HrcA_DNA-bdg; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repressor; Stress response; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..347
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_0000182487"
SQ   SEQUENCE   347 AA;  39863 MW;  04F2E19C1D300430 CRC64;
     MITERQRQIL NLIVSLYAKE HTPIGSKSLL DSIQASSATI RNDMKVLEKL GLIQKEHTSS
     GRVPSVSGYK YFVENVIQLD EFSQNDLFKV MKAFDGDFYR LSDLFKTAAK SLSGLTGLTS
     FVLNAPQRDQ QLVSFEMVML DSHSVLSVIT LGTGEVRTNQ FILPKSMTEA DLAVFSNLVK
     ERLVGKKVID IHYTLRTEIP QIVQRYFKVT SEVLQLFESI FDDLFKERLT VAGRKNIFDY
     ATDNLAELYK LFSDDERMLH EIREITNNDE MRAVKFDNDE KYMKNLTIIS QKFVIPYRGF
     GTLTVVGPVE MDYQRTLSVL DLVAKVLTMK LSDYYRYLDG NHYEISK