ID   HRCA_LACLM              Reviewed;         347 AA.
AC   P42370; A2RLI3;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 109.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=llmg_1576;
OS   Lactococcus lactis subsp. cremoris (strain MG1363).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Lactococcus; Lactococcus cremoris subsp. cremoris.
OX   NCBI_TaxID=416870;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8126443; DOI=10.1099/00221287-139-12-3253;
RA   Eaton T.J., Shearman C.A., Gasson M.J.;
RT   "Cloning and sequence analysis of the dnaK gene region of Lactococcus
RT   lactis subsp. lactis.";
RL   J. Gen. Microbiol. 139:3253-3263(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MG1363;
RX   PubMed=17307855; DOI=10.1128/jb.01768-06;
RA   Wegmann U., O'Connell-Motherway M., Zomer A., Buist G., Shearman C.,
RA   Canchaya C., Ventura M., Goesmann A., Gasson M.J., Kuipers O.P.,
RA   van Sinderen D., Kok J.;
RT   "The complete genome sequence of the lactic acid bacterial paradigm
RT   Lactococcus lactis subsp. cremoris MG1363.";
RL   J. Bacteriol. 189:3256-3270(2007).
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; X76642; CAA54087.1; -; Genomic_DNA.
DR   EMBL; AM406671; CAL98151.1; -; Genomic_DNA.
DR   PIR; S40082; S40082.
DR   RefSeq; WP_011835410.1; NZ_WJVF01000018.1.
DR   AlphaFoldDB; P42370; -.
DR   SMR; P42370; -.
DR   STRING; 416870.llmg_1576; -.
DR   EnsemblBacteria; CAL98151; CAL98151; llmg_1576.
DR   KEGG; llm:llmg_1576; -.
DR   eggNOG; COG1420; Bacteria.
DR   HOGENOM; CLU_050019_1_0_9; -.
DR   OMA; DYPGTMG; -.
DR   PhylomeDB; P42370; -.
DR   BioCyc; LLAC416870:LLMG_RS07940-MON; -.
DR   Proteomes; UP000000364; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR005104; WHTH_HrcA_DNA-bd.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   Pfam; PF03444; HrcA_DNA-bdg; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Repressor; Stress response; Transcription; Transcription regulation.
FT   CHAIN           1..347
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_0000182488"
SQ   SEQUENCE   347 AA;  39922 MW;  1B365057495CD5F9 CRC64;
     MITERQRQIL NLIVSLYAKD HTPIGSKSLL DSIQASSATI RNDMKALERL GLIQKEHTSS
     GRIPSVSGYK YFVENVIQLE EFSQNDLFKV MKAFDGDFYR LSDLFKTAAK SLSELTGLTS
     FVLNAPQRDQ QLVSFEMVML DNHSVLSVIT LGTGEVRTNQ FILPKSMTEA DLAVFSNLVK
     ERLVGKKVID IHYTLRTEIP QIVQRYFKVT SEVLQLFESI FDDLFKEHLT VAGHKNIFDY
     ATDNLAELYK LFSDDERMLH EIREITNNDE MRAVKFDNDE KFMKNLTIIS QKFVIPYRGF
     GTLTVVGPVE MDYQRTLSVL DLVAKVLTMK LSDYYRYLDG NHYEISK