HRCA_LACPL
ID HRCA_LACPL Reviewed; 347 AA.
AC Q88VL8; F9UPY6;
DT 31-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 99.
DE RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=lp_2029;
OS Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)
OS (Lactobacillus plantarum).
OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC Lactiplantibacillus.
OX NCBI_TaxID=220668;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-793 / NCIMB 8826 / WCFS1;
RX PubMed=12566566; DOI=10.1073/pnas.0337704100;
RA Kleerebezem M., Boekhorst J., van Kranenburg R., Molenaar D., Kuipers O.P.,
RA Leer R., Tarchini R., Peters S.A., Sandbrink H.M., Fiers M.W.E.J.,
RA Stiekema W., Klein Lankhorst R.M., Bron P.A., Hoffer S.M.,
RA Nierop Groot M.N., Kerkhoven R., De Vries M., Ursing B., De Vos W.M.,
RA Siezen R.J.;
RT "Complete genome sequence of Lactobacillus plantarum WCFS1.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:1990-1995(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=ATCC BAA-793 / NCIMB 8826 / WCFS1;
RX PubMed=22156394; DOI=10.1128/jb.06275-11;
RA Siezen R.J., Francke C., Renckens B., Boekhorst J., Wels M.,
RA Kleerebezem M., van Hijum S.A.;
RT "Complete resequencing and reannotation of the Lactobacillus plantarum
RT WCFS1 genome.";
RL J. Bacteriol. 194:195-196(2012).
CC -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC dnaJ and groELS operons). Prevents heat-shock induction of these
CC operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC Rule:MF_00081}.
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DR EMBL; AL935263; CCC79275.1; -; Genomic_DNA.
DR RefSeq; WP_003640713.1; NC_004567.2.
DR RefSeq; YP_004889789.1; NC_004567.2.
DR AlphaFoldDB; Q88VL8; -.
DR SMR; Q88VL8; -.
DR STRING; 220668.lp_2029; -.
DR EnsemblBacteria; CCC79275; CCC79275; lp_2029.
DR GeneID; 57025581; -.
DR KEGG; lpl:lp_2029; -.
DR PATRIC; fig|220668.9.peg.1714; -.
DR eggNOG; COG1420; Bacteria.
DR HOGENOM; CLU_050019_1_0_9; -.
DR OMA; DYPGTMG; -.
DR PhylomeDB; Q88VL8; -.
DR BioCyc; LPLA220668:G1GW0-1736-MON; -.
DR Proteomes; UP000000432; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.10.10; -; 1.
DR Gene3D; 3.30.390.60; -; 1.
DR Gene3D; 3.30.450.40; -; 1.
DR HAMAP; MF_00081; HrcA; 1.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR002571; HrcA.
DR InterPro; IPR021153; HrcA_C.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR InterPro; IPR005104; WHTH_HrcA_DNA-bd.
DR InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR PANTHER; PTHR34824; PTHR34824; 1.
DR Pfam; PF01628; HrcA; 1.
DR Pfam; PF03444; HrcA_DNA-bdg; 1.
DR PIRSF; PIRSF005485; HrcA; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR TIGRFAMs; TIGR00331; hrcA; 1.
PE 3: Inferred from homology;
KW Reference proteome; Repressor; Stress response; Transcription;
KW Transcription regulation.
FT CHAIN 1..347
FT /note="Heat-inducible transcription repressor HrcA"
FT /id="PRO_0000182489"
SQ SEQUENCE 347 AA; 38909 MW; FD9420DF820CDF57 CRC64;
MITLTERQSL ILKAIVRDYT EGGNPVGSKS LVQELPIKVS SATIRNEMAR LEDLGLIVKT
HLSSGRIPSI KGYRYYVDHI LKPEKVDGKD LKVIQHSLGG EFHKIDEIVA QSADILSQLT
SYTTFTLRPE LKDSRLSGFR LVPLGNHQVM AILVTNNGDV ENQTFTIPSD ITGDELEPVV
RFIDDQLVGL PLQDVLRQLT HEIPLKLAQY LQDPDGFLDI FGSVLSKAAS ERFYVGGKLN
LFNYTDQQSP KELQSLYSLL DQTDRLANVI GPPGQRIQVR IGNEITNDLL KNYSLITATY
DVDQHGQGVI ALLGPTAMPY SRMIGLMGAF QRELARKLLD YYRYFDE
