ID   HRCA_LATSK              Reviewed;         352 AA.
AC   O87775;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   25-MAY-2022, entry version 87.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081};
OS   Latilactobacillus sakei (Lactobacillus sakei).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Latilactobacillus.
OX   NCBI_TaxID=1599;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=LTH681;
RA   Schmidt G., Hertel C., Hammes W.P.;
RT   "Cloning and sequence analysis of the dnaK operon of Lactobacillus sakei
RT   LTH681.";
RL   Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; AJ006274; CAA06939.1; -; Genomic_DNA.
DR   RefSeq; WP_016265327.1; NZ_MKDO01000005.1.
DR   AlphaFoldDB; O87775; -.
DR   SMR; O87775; -.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR005104; WHTH_HrcA_DNA-bd.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   Pfam; PF03444; HrcA_DNA-bdg; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Repressor; Stress response; Transcription; Transcription regulation.
FT   CHAIN           1..352
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_0000182490"
SQ   SEQUENCE   352 AA;  39011 MW;  9E2A289AED68C7AB CRC64;
     MLTERQLMIL KEIIRLFTES GQPVGSKKLM SELPMHVSSA TIRNDMADLE NVGLIEKTHS
     SSGRVPSMKG YRYYLDHLIQ PAVLNPMDVA TVQQSFGRHY HKIDEIVSQS ANILSNLTSY
     TAITLGPEMA EIRLTGFRLV PLGNHQVMAI IVTSAGTVDN QVFTIPNAIS GDELEKAIRV
     VNDHLIGLPL TVVSQKLKTE VPALLMQYMG SPGGFLNIFD DVLKQASQER LYVGGQSNLL
     NFSELTDVSQ LKSIYNIINQ SDDLAKLLEL SPGEANSQVQ VRLGDEMTND LLKNYSLMTV
     NYDVGEHGQG LIALLGPTSM PHSRMIGLLD LFREELAKKL IDYYADFDDN QS