ID   HRCA_LEPBA              Reviewed;         343 AA.
AC   B0SHT3;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=LBF_3267;
OS   Leptospira biflexa serovar Patoc (strain Patoc 1 / Ames).
OC   Bacteria; Spirochaetes; Leptospirales; Leptospiraceae; Leptospira.
OX   NCBI_TaxID=355278;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Patoc 1 / Ames;
RX   PubMed=18270594; DOI=10.1371/journal.pone.0001607;
RA   Picardeau M., Bulach D.M., Bouchier C., Zuerner R.L., Zidane N.,
RA   Wilson P.J., Creno S., Kuczek E.S., Bommezzadri S., Davis J.C., McGrath A.,
RA   Johnson M.J., Boursaux-Eude C., Seemann T., Rouy Z., Coppel R.L.,
RA   Rood J.I., Lajus A., Davies J.K., Medigue C., Adler B.;
RT   "Genome sequence of the saprophyte Leptospira biflexa provides insights
RT   into the evolution of Leptospira and the pathogenesis of leptospirosis.";
RL   PLoS ONE 3:E1607-E1607(2008).
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; CP000777; ABZ95734.1; -; Genomic_DNA.
DR   RefSeq; WP_012476458.1; NC_010842.1.
DR   AlphaFoldDB; B0SHT3; -.
DR   SMR; B0SHT3; -.
DR   PRIDE; B0SHT3; -.
DR   KEGG; lbf:LBF_3267; -.
DR   HOGENOM; CLU_050019_1_0_12; -.
DR   OMA; DYPGTMG; -.
DR   BioCyc; LBIF355278:LBF_RS16600-MON; -.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Repressor; Stress response; Transcription; Transcription regulation.
FT   CHAIN           1..343
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_1000092816"
SQ   SEQUENCE   343 AA;  38932 MW;  809CE2C9044373B3 CRC64;
     MDLSPRHRSI LKALVEEFVS DNKPVGSKTL SEKYDIGLSP ATIRSCLAEL EDMGFIVARH
     TSGGRVPTER GYRLYVDSLV TLFELTMREK QRIQEEYLRM QFRLDQVLIA TSKVLASLSQ
     SASVVLGPEG SLDTLKHIEL IHVNGGEVLM ILVMRSGTVL NRNIFFDFHI SQETLYQISR
     YLNDNVKGFD VHEIQSNLIP QMMLKKEGPE GFTLFAPSIA RAMGTDSHSV DNLYIDGLKN
     LYENFKDEEE QLENILHLFD EKQFLKEFFS DYVPMDGVYT IIGKDGNEKL GGVTIITTNY
     RMGEKRIGSM GIIGPQRMNY NKALPLIEFT SKLVSEMITK LSR