ID   HRCA_LEPCP              Reviewed;         341 AA.
AC   B1Y3N8;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   20-MAY-2008, sequence version 1.
DT   25-MAY-2022, entry version 80.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=Lcho_3487;
OS   Leptothrix cholodnii (strain ATCC 51168 / LMG 8142 / SP-6) (Leptothrix
OS   discophora (strain SP-6)).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales; Leptothrix.
OX   NCBI_TaxID=395495;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51168 / LMG 8142 / SP-6;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA   Bruce D., Goodwin L., Pitluck S., Chertkov O., Brettin T., Detter J.C.,
RA   Han C., Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L.,
RA   Kyrpides N., Lykidis A., Emerson D., Richardson P.;
RT   "Complete sequence of Leptothrix cholodnii SP-6.";
RL   Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; CP001013; ACB35741.1; -; Genomic_DNA.
DR   RefSeq; WP_012348488.1; NC_010524.1.
DR   AlphaFoldDB; B1Y3N8; -.
DR   SMR; B1Y3N8; -.
DR   STRING; 395495.Lcho_3487; -.
DR   EnsemblBacteria; ACB35741; ACB35741; Lcho_3487.
DR   KEGG; lch:Lcho_3487; -.
DR   eggNOG; COG1420; Bacteria.
DR   HOGENOM; CLU_050019_0_0_4; -.
DR   OMA; DYPGTMG; -.
DR   OrthoDB; 1510750at2; -.
DR   Proteomes; UP000001693; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR005104; WHTH_HrcA_DNA-bd.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   Pfam; PF03444; HrcA_DNA-bdg; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repressor; Stress response; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..341
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_1000118304"
SQ   SEQUENCE   341 AA;  37154 MW;  1A5357E793A38357 CRC64;
     MLDERAKMLL KTLVERYIAD GQPVGSRTLS KTSGLELSPA TIRNVMSDLE ELGLIASPHT
     SAGRIPTARG YRLFVDSMLT SRAFAREVAD TGSAPLLQPD QPKRVIANAA QLLSSLSQFV
     GVVTVPKKPS VFRHMEFLRL GERRVLLILV SPDGDVQNRV LFTAHDYTQS QLVEATNYLN
     AHYAGLSIEG VRERLKLEVD ALRGEIGTLM QAAVQAGTEA VNEDTEQLIV SGERNLLGVQ
     DFGSDMGSIR KMFDLFEQKT QLLRLLDGSS RADGVRIYIG GESGVVPIEE LSVVSAPYEV
     DGQVVGTLGV IGPTRMAYER MIQIVDITSR LVGNALSQKQ G