ID   HRCA_LEPIC              Reviewed;         342 AA.
AC   P61446; O51867;
DT   24-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2004, sequence version 1.
DT   25-MAY-2022, entry version 99.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=LIC_10526;
OS   Leptospira interrogans serogroup Icterohaemorrhagiae serovar copenhageni
OS   (strain Fiocruz L1-130).
OC   Bacteria; Spirochaetes; Leptospirales; Leptospiraceae; Leptospira.
OX   NCBI_TaxID=267671;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Wijnberg;
RX   PubMed=9714717; DOI=10.1016/s0378-1119(98)00329-1;
RA   Ballard S.A., Go M., Segers R.P.A.M., Adler B.;
RT   "Molecular analysis of the dnaK locus of Leptospira interrogans serovar
RT   Copenhageni.";
RL   Gene 216:21-29(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Fiocruz L1-130;
RX   PubMed=15028702; DOI=10.1128/jb.186.7.2164-2172.2004;
RA   Nascimento A.L.T.O., Ko A.I., Martins E.A.L., Monteiro-Vitorello C.B.,
RA   Ho P.L., Haake D.A., Verjovski-Almeida S., Hartskeerl R.A., Marques M.V.,
RA   Oliveira M.C., Menck C.F.M., Leite L.C.C., Carrer H., Coutinho L.L.,
RA   Degrave W.M., Dellagostin O.A., El-Dorry H., Ferro E.S., Ferro M.I.T.,
RA   Furlan L.R., Gamberini M., Giglioti E.A., Goes-Neto A., Goldman G.H.,
RA   Goldman M.H.S., Harakava R., Jeronimo S.M.B., Junqueira-de-Azevedo I.L.M.,
RA   Kimura E.T., Kuramae E.E., Lemos E.G.M., Lemos M.V.F., Marino C.L.,
RA   Nunes L.R., de Oliveira R.C., Pereira G.G., Reis M.S., Schriefer A.,
RA   Siqueira W.J., Sommer P., Tsai S.M., Simpson A.J.G., Ferro J.A.,
RA   Camargo L.E.A., Kitajima J.P., Setubal J.C., Van Sluys M.A.;
RT   "Comparative genomics of two Leptospira interrogans serovars reveals novel
RT   insights into physiology and pathogenesis.";
RL   J. Bacteriol. 186:2164-2172(2004).
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; AF007813; AAC35414.1; -; Genomic_DNA.
DR   EMBL; AE016823; AAS69147.1; -; Genomic_DNA.
DR   RefSeq; WP_000366219.1; NC_005823.1.
DR   AlphaFoldDB; P61446; -.
DR   SMR; P61446; -.
DR   PaxDb; P61446; -.
DR   PRIDE; P61446; -.
DR   EnsemblBacteria; AAS69147; AAS69147; LIC_10526.
DR   GeneID; 61143881; -.
DR   KEGG; lic:LIC_10526; -.
DR   HOGENOM; CLU_050019_1_0_12; -.
DR   OMA; DYPGTMG; -.
DR   Proteomes; UP000007037; Chromosome I.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Repressor; Stress response; Transcription; Transcription regulation.
FT   CHAIN           1..342
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_0000182493"
FT   CONFLICT        17
FT                   /note="E -> K (in Ref. 1; AAC35414)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   342 AA;  38877 MW;  1B064B4451091CC3 CRC64;
     MDLTERHKRI LKALVDEFIQ ENRPVGSKTL FDKHDIGLSP ASIRTVLKDL EDFGYLASKH
     TSGGRIPTER GYRFYVDSLV ILYELTLKEK QRIQQEYLKM QFKLDQILKA TASVLSSLSN
     AAGIVIGPAK NLDTLKHIEL IHVRGDEILM ILVMRSGTVL HRNIFVDQNY SQEALYQVSK
     YLNDNLKGYD IYEIQNVIIP KLMIRKDGPE DFIRIADLIS SAMTPDNSEV TLYIDGFKNL
     YANFRDEEQQ LSQVLSLLDD QGFLKAFFSE YIDQDGVFTI IGKDGDRSMS GVSIITSNYK
     MGEKKIGALG IIGPQRMDYN RALPLVDFTS KLVSEMVTRI SK