ID   HRCA_LEPIN              Reviewed;         342 AA.
AC   P61447; O51867;
DT   24-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2004, sequence version 1.
DT   25-MAY-2022, entry version 93.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=LA_3703;
OS   Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain
OS   56601).
OC   Bacteria; Spirochaetes; Leptospirales; Leptospiraceae; Leptospira.
OX   NCBI_TaxID=189518;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=56601;
RX   PubMed=12712204; DOI=10.1038/nature01597;
RA   Ren S.-X., Fu G., Jiang X.-G., Zeng R., Miao Y.-G., Xu H., Zhang Y.-X.,
RA   Xiong H., Lu G., Lu L.-F., Jiang H.-Q., Jia J., Tu Y.-F., Jiang J.-X.,
RA   Gu W.-Y., Zhang Y.-Q., Cai Z., Sheng H.-H., Yin H.-F., Zhang Y., Zhu G.-F.,
RA   Wan M., Huang H.-L., Qian Z., Wang S.-Y., Ma W., Yao Z.-J., Shen Y.,
RA   Qiang B.-Q., Xia Q.-C., Guo X.-K., Danchin A., Saint Girons I.,
RA   Somerville R.L., Wen Y.-M., Shi M.-H., Chen Z., Xu J.-G., Zhao G.-P.;
RT   "Unique physiological and pathogenic features of Leptospira interrogans
RT   revealed by whole-genome sequencing.";
RL   Nature 422:888-893(2003).
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; AE010300; AAN50901.1; -; Genomic_DNA.
DR   RefSeq; NP_713883.1; NC_004342.2.
DR   RefSeq; WP_000366219.1; NC_004342.2.
DR   AlphaFoldDB; P61447; -.
DR   SMR; P61447; -.
DR   STRING; 189518.LA_3703; -.
DR   EnsemblBacteria; AAN50901; AAN50901; LA_3703.
DR   GeneID; 61143881; -.
DR   KEGG; lil:LA_3703; -.
DR   PATRIC; fig|189518.3.peg.3678; -.
DR   HOGENOM; CLU_050019_1_0_12; -.
DR   InParanoid; P61447; -.
DR   OMA; DYPGTMG; -.
DR   Proteomes; UP000001408; Chromosome I.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IBA:GO_Central.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repressor; Stress response; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..342
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_0000182494"
SQ   SEQUENCE   342 AA;  38877 MW;  1B064B4451091CC3 CRC64;
     MDLTERHKRI LKALVDEFIQ ENRPVGSKTL FDKHDIGLSP ASIRTVLKDL EDFGYLASKH
     TSGGRIPTER GYRFYVDSLV ILYELTLKEK QRIQQEYLKM QFKLDQILKA TASVLSSLSN
     AAGIVIGPAK NLDTLKHIEL IHVRGDEILM ILVMRSGTVL HRNIFVDQNY SQEALYQVSK
     YLNDNLKGYD IYEIQNVIIP KLMIRKDGPE DFIRIADLIS SAMTPDNSEV TLYIDGFKNL
     YANFRDEEQQ LSQVLSLLDD QGFLKAFFSE YIDQDGVFTI IGKDGDRSMS GVSIITSNYK
     MGEKKIGALG IIGPQRMDYN RALPLVDFTS KLVSEMVTRI SK