ID   HRCA_LIGS1              Reviewed;         350 AA.
AC   Q1WUF0;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   02-MAY-2006, sequence version 1.
DT   25-MAY-2022, entry version 95.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=LSL_0576;
OS   Ligilactobacillus salivarius (strain UCC118) (Lactobacillus salivarius).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Ligilactobacillus.
OX   NCBI_TaxID=362948;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UCC118;
RX   PubMed=16617113; DOI=10.1073/pnas.0511060103;
RA   Claesson M.J., Li Y., Leahy S., Canchaya C., van Pijkeren J.P.,
RA   Cerdeno-Tarraga A.M., Parkhill J., Flynn S., O'Sullivan G.C., Collins J.K.,
RA   Higgins D., Shanahan F., Fitzgerald G.F., van Sinderen D., O'Toole P.W.;
RT   "Multireplicon genome architecture of Lactobacillus salivarius.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:6718-6723(2006).
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; CP000233; ABD99385.1; -; Genomic_DNA.
DR   RefSeq; WP_003703155.1; NC_007929.1.
DR   RefSeq; YP_535468.1; NC_007929.1.
DR   AlphaFoldDB; Q1WUF0; -.
DR   SMR; Q1WUF0; -.
DR   STRING; 362948.LSL_0576; -.
DR   EnsemblBacteria; ABD99385; ABD99385; LSL_0576.
DR   GeneID; 57059066; -.
DR   KEGG; lsl:LSL_0576; -.
DR   PATRIC; fig|362948.14.peg.655; -.
DR   HOGENOM; CLU_050019_1_0_9; -.
DR   OMA; DYPGTMG; -.
DR   Proteomes; UP000006559; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repressor; Stress response; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..350
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_1000010415"
SQ   SEQUENCE   350 AA;  39173 MW;  010F7B39CB34680C CRC64;
     MLTERQLLIL ETIIRDYTDL GQPIGSKTLQ EQLPIRVSSA TIRNEMAVLE KQGFITKEHS
     SSGRIPSLKG YRYYVDNLVK PVKIDSKSVR SIQSLFGNEY RRVDEIIEMS AKILSDLTNY
     TAITLRPEAS DLKLEGFRMV PLGNGQVMVI LVASDGSVES QIYNLPNNID GESLEAVIRL
     INDKLVGSSL SEVTSKLQEL QPLLTKYIEK SDGFIDVFGG ILDKAIKEQF YIGGRRNLLN
     FANGNNLEQI KSLYSLIDDE SDKIGGLVDN TTNPHDHHGI SVKIGDEMSD RLLLDYSLVS
     ATYNVGSHGR GMIAILGPTN MPYSKMIGLV EVFQKELTKK LIDYYRNFDK