ID   HRCA_LIMRD              Reviewed;         350 AA.
AC   A5VJE5;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   10-JUL-2007, sequence version 1.
DT   25-MAY-2022, entry version 86.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=Lreu_0704;
OS   Limosilactobacillus reuteri (strain DSM 20016) (Lactobacillus reuteri).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Limosilactobacillus.
OX   NCBI_TaxID=557436;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 20016;
RX   PubMed=21379339; DOI=10.1371/journal.pgen.1001314;
RA   Frese S.A., Benson A.K., Tannock G.W., Loach D.M., Kim J., Zhang M.,
RA   Oh P.L., Heng N.C., Patil P.B., Juge N., Mackenzie D.A., Pearson B.M.,
RA   Lapidus A., Dalin E., Tice H., Goltsman E., Land M., Hauser L., Ivanova N.,
RA   Kyrpides N.C., Walter J.;
RT   "The evolution of host specialization in the vertebrate gut symbiont
RT   Lactobacillus reuteri.";
RL   PLoS Genet. 7:E1001314-E1001314(2011).
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; CP000705; ABQ82969.1; -; Genomic_DNA.
DR   RefSeq; WP_003668173.1; NZ_AZDD01000017.1.
DR   AlphaFoldDB; A5VJE5; -.
DR   SMR; A5VJE5; -.
DR   STRING; 557436.Lreu_0704; -.
DR   EnsemblBacteria; ABQ82969; ABQ82969; Lreu_0704.
DR   GeneID; 66470845; -.
DR   KEGG; lre:Lreu_0704; -.
DR   PATRIC; fig|557436.17.peg.551; -.
DR   eggNOG; COG1420; Bacteria.
DR   HOGENOM; CLU_050019_1_0_9; -.
DR   OMA; DYPGTMG; -.
DR   Proteomes; UP000001991; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR005104; WHTH_HrcA_DNA-bd.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   Pfam; PF03444; HrcA_DNA-bdg; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repressor; Stress response; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..350
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_1000057535"
SQ   SEQUENCE   350 AA;  39225 MW;  4C4FF4F2BB66FA93 CRC64;
     MLTQRQKKIL QAIVRQYTST GQPVGSKHLA EKLPFKVSSA TVRNEMAVLE DNDLILKEHS
     SSGRIPSKRG YRYYVDNLLD PQAVTDNDLV VIQNSLGNGF QKIDEIISHS ADILSNLTSY
     TAFTLKPEQE SVRLSGFRVV PLGNHKVIAI LVTDSGEVEN QSFTLPPDID TDAMQAVIRM
     INDQLVGLPL SEVVKRLKDD IPLQVLHYMH SPDGFLDIFD NVLSQAARER FFVGGRLNLL
     DFASTHDPHA IQSLYGLLDK NDNLSNILDS TLTSDNGVNV KIGQEISKNK LLDDYSLITA
     SYNVEQYGRG IIAVLGPTRM PYSRTIGIVN AFRQELAKRL LDFYRHYYDS