ID   HRCA_LISM4              Reviewed;         345 AA.
AC   G2K048; Q9S5A6;
DT   05-SEP-2012, integrated into UniProtKB/Swiss-Prot.
DT   16-NOV-2011, sequence version 1.
DT   25-MAY-2022, entry version 49.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=LMRG_00928;
OS   Listeria monocytogenes serotype 1/2a (strain 10403S).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Listeriaceae; Listeria.
OX   NCBI_TaxID=393133;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=10403S;
RX   PubMed=10701836; DOI=10.1379/1466-1268(2000)005<0021:csatao>2.0.co;2;
RA   Hanawa T., Kai M., Kamiya S., Yamamoto T.;
RT   "Cloning, sequencing, and transcriptional analysis of the dnaK heat shock
RT   operon of Listeria monocytogenes.";
RL   Cell Stress Chaperones 5:21-29(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=10403S;
RG   The Broad Institute Genome Sequencing Platform;
RG   The Broad Institute Genome Sequencing Center for Infectious Disease;
RA   Borowsky M., Borodovsky M., Young S.K., Zeng Q., Koehrsen M.,
RA   Fitzgerald M., Wiedmann M., Swaminathan B., Lauer P., Portnoy D.,
RA   Cossart P., Buchrieser C., Higgins D., Abouelleil A., Alvarado L.,
RA   Arachchi H.M., Berlin A., Borenstein D., Brown A., Chapman S.B., Chen Z.,
RA   Dunbar C.D., Engels R., Freedman E., Gearin G., Gellesch M., Goldberg J.,
RA   Griggs A., Gujja S., Heilman E., Heiman D., Howarth C., Jen D., Larson L.,
RA   Lui A., MacDonald J., Mehta T., Montmayeur A., Neiman D., Park D.,
RA   Pearson M., Priest M., Richards J., Roberts A., Saif S., Shea T.,
RA   Shenoy N., Sisk P., Stolte C., Sykes S., Walk T., White J., Yandava C.,
RA   Haas B., Nusbaum C., Birren B.;
RT   "The genome sequence of Listeria monocytogenes strain 10403S.";
RL   Submitted (APR-2010) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AB023064; BAA82787.1; -; Genomic_DNA.
DR   EMBL; CP002002; AEO06460.1; -; Genomic_DNA.
DR   PIR; T43736; T43736.
DR   RefSeq; WP_003726026.1; NC_017544.1.
DR   AlphaFoldDB; G2K048; -.
DR   SMR; G2K048; -.
DR   EnsemblBacteria; AEO06460; AEO06460; LMRG_00928.
DR   KEGG; lmt:LMRG_00928; -.
DR   HOGENOM; CLU_050019_1_0_9; -.
DR   OMA; DYPGTMG; -.
DR   Proteomes; UP000001288; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Repressor; Stress response; Transcription; Transcription regulation.
FT   CHAIN           1..345
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_0000418524"
SQ   SEQUENCE   345 AA;  39681 MW;  F3BFE25C1E415995 CRC64;
     MLTERQLLIF RAIIDHFTWT IQPVGSKNLL KEKGLPYSSA TIRNEMGVLE EYGFIEKTHS
     SSGRVPSEKG YRFYVDYLLQ PKKLDKSDRQ MIRSFFSENY YEMEGLIQNS ALMLSDLTNY
     TSILLGPEAT KNHLSGFRFV PINNFQAMLI LITDQGHVDN HLVTIPEGTT LSDIERMVNI
     LNERLVGLSL DDLKVQIPME VKELLGKHVR NYESFMHVFS DSFAQASQQK VYFGGKTNIL
     NQPEFHDINK VREMLHLMEE EQDVYELFRD IPDGLQVKIG RENNNSLMED CSIITATYNI
     AGERVGGIVL LGPTRMEYSR MMGLVDVMSR DLTDVLTKLY RDNQN