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HRCA_LISMC
ID   HRCA_LISMC              Reviewed;         345 AA.
AC   C1KVC2;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   26-MAY-2009, sequence version 1.
DT   03-AUG-2022, entry version 67.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=Lm4b_01485;
OS   Listeria monocytogenes serotype 4b (strain CLIP80459).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Listeriaceae; Listeria.
OX   NCBI_TaxID=568819;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CLIP80459;
RX   PubMed=22530965; DOI=10.1186/1471-2164-13-144;
RA   Hain T., Ghai R., Billion A., Kuenne C.T., Steinweg C., Izar B.,
RA   Mohamed W., Mraheil M., Domann E., Schaffrath S., Karst U., Goesmann A.,
RA   Oehm S., Puhler A., Merkl R., Vorwerk S., Glaser P., Garrido P.,
RA   Rusniok C., Buchrieser C., Goebel W., Chakraborty T.;
RT   "Comparative genomics and transcriptomics of lineages I, II, and III
RT   strains of Listeria monocytogenes.";
RL   BMC Genomics 13:144-144(2012).
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; FM242711; CAS05247.1; -; Genomic_DNA.
DR   RefSeq; WP_003726026.1; NC_012488.1.
DR   AlphaFoldDB; C1KVC2; -.
DR   SMR; C1KVC2; -.
DR   KEGG; lmc:Lm4b_01485; -.
DR   HOGENOM; CLU_050019_1_0_9; -.
DR   OMA; DYPGTMG; -.
DR   BioCyc; LMON568819:LM4B_RS07405-MON; -.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Repressor; Stress response; Transcription; Transcription regulation.
FT   CHAIN           1..345
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_1000202552"
SQ   SEQUENCE   345 AA;  39681 MW;  F3BFE25C1E415995 CRC64;
     MLTERQLLIF RAIIDHFTWT IQPVGSKNLL KEKGLPYSSA TIRNEMGVLE EYGFIEKTHS
     SSGRVPSEKG YRFYVDYLLQ PKKLDKSDRQ MIRSFFSENY YEMEGLIQNS ALMLSDLTNY
     TSILLGPEAT KNHLSGFRFV PINNFQAMLI LITDQGHVDN HLVTIPEGTT LSDIERMVNI
     LNERLVGLSL DDLKVQIPME VKELLGKHVR NYESFMHVFS DSFAQASQQK VYFGGKTNIL
     NQPEFHDINK VREMLHLMEE EQDVYELFRD IPDGLQVKIG RENNNSLMED CSIITATYNI
     AGERVGGIVL LGPTRMEYSR MMGLVDVMSR DLTDVLTKLY RDNQN
 
 
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