HRCA_LISMC
ID HRCA_LISMC Reviewed; 345 AA.
AC C1KVC2;
DT 22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT 26-MAY-2009, sequence version 1.
DT 03-AUG-2022, entry version 67.
DE RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=Lm4b_01485;
OS Listeria monocytogenes serotype 4b (strain CLIP80459).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Listeriaceae; Listeria.
OX NCBI_TaxID=568819;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CLIP80459;
RX PubMed=22530965; DOI=10.1186/1471-2164-13-144;
RA Hain T., Ghai R., Billion A., Kuenne C.T., Steinweg C., Izar B.,
RA Mohamed W., Mraheil M., Domann E., Schaffrath S., Karst U., Goesmann A.,
RA Oehm S., Puhler A., Merkl R., Vorwerk S., Glaser P., Garrido P.,
RA Rusniok C., Buchrieser C., Goebel W., Chakraborty T.;
RT "Comparative genomics and transcriptomics of lineages I, II, and III
RT strains of Listeria monocytogenes.";
RL BMC Genomics 13:144-144(2012).
CC -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC dnaJ and groELS operons). Prevents heat-shock induction of these
CC operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC Rule:MF_00081}.
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DR EMBL; FM242711; CAS05247.1; -; Genomic_DNA.
DR RefSeq; WP_003726026.1; NC_012488.1.
DR AlphaFoldDB; C1KVC2; -.
DR SMR; C1KVC2; -.
DR KEGG; lmc:Lm4b_01485; -.
DR HOGENOM; CLU_050019_1_0_9; -.
DR OMA; DYPGTMG; -.
DR BioCyc; LMON568819:LM4B_RS07405-MON; -.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.10.10; -; 1.
DR Gene3D; 3.30.390.60; -; 1.
DR Gene3D; 3.30.450.40; -; 1.
DR HAMAP; MF_00081; HrcA; 1.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR002571; HrcA.
DR InterPro; IPR021153; HrcA_C.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR PANTHER; PTHR34824; PTHR34824; 1.
DR Pfam; PF01628; HrcA; 1.
DR PIRSF; PIRSF005485; HrcA; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR TIGRFAMs; TIGR00331; hrcA; 1.
PE 3: Inferred from homology;
KW Repressor; Stress response; Transcription; Transcription regulation.
FT CHAIN 1..345
FT /note="Heat-inducible transcription repressor HrcA"
FT /id="PRO_1000202552"
SQ SEQUENCE 345 AA; 39681 MW; F3BFE25C1E415995 CRC64;
MLTERQLLIF RAIIDHFTWT IQPVGSKNLL KEKGLPYSSA TIRNEMGVLE EYGFIEKTHS
SSGRVPSEKG YRFYVDYLLQ PKKLDKSDRQ MIRSFFSENY YEMEGLIQNS ALMLSDLTNY
TSILLGPEAT KNHLSGFRFV PINNFQAMLI LITDQGHVDN HLVTIPEGTT LSDIERMVNI
LNERLVGLSL DDLKVQIPME VKELLGKHVR NYESFMHVFS DSFAQASQQK VYFGGKTNIL
NQPEFHDINK VREMLHLMEE EQDVYELFRD IPDGLQVKIG RENNNSLMED CSIITATYNI
AGERVGGIVL LGPTRMEYSR MMGLVDVMSR DLTDVLTKLY RDNQN