ID   HRCA_LISMO              Reviewed;         345 AA.
AC   P0DJM4; Q9S5A6;
DT   05-SEP-2012, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2012, sequence version 1.
DT   03-AUG-2022, entry version 47.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=lmo1475;
OS   Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Listeriaceae; Listeria.
OX   NCBI_TaxID=169963;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-679 / EGD-e;
RX   PubMed=11679669; DOI=10.1126/science.1063447;
RA   Glaser P., Frangeul L., Buchrieser C., Rusniok C., Amend A., Baquero F.,
RA   Berche P., Bloecker H., Brandt P., Chakraborty T., Charbit A.,
RA   Chetouani F., Couve E., de Daruvar A., Dehoux P., Domann E.,
RA   Dominguez-Bernal G., Duchaud E., Durant L., Dussurget O., Entian K.-D.,
RA   Fsihi H., Garcia-del Portillo F., Garrido P., Gautier L., Goebel W.,
RA   Gomez-Lopez N., Hain T., Hauf J., Jackson D., Jones L.-M., Kaerst U.,
RA   Kreft J., Kuhn M., Kunst F., Kurapkat G., Madueno E., Maitournam A.,
RA   Mata Vicente J., Ng E., Nedjari H., Nordsiek G., Novella S., de Pablos B.,
RA   Perez-Diaz J.-C., Purcell R., Remmel B., Rose M., Schlueter T., Simoes N.,
RA   Tierrez A., Vazquez-Boland J.-A., Voss H., Wehland J., Cossart P.;
RT   "Comparative genomics of Listeria species.";
RL   Science 294:849-852(2001).
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; AL591979; CAC99553.1; -; Genomic_DNA.
DR   PIR; AC1259; AC1259.
DR   RefSeq; NP_465000.1; NC_003210.1.
DR   RefSeq; WP_003726026.1; NZ_CP023861.1.
DR   AlphaFoldDB; P0DJM4; -.
DR   SMR; P0DJM4; -.
DR   STRING; 169963.lmo1475; -.
DR   PaxDb; P0DJM4; -.
DR   EnsemblBacteria; CAC99553; CAC99553; CAC99553.
DR   GeneID; 986933; -.
DR   KEGG; lmo:lmo1475; -.
DR   PATRIC; fig|169963.11.peg.1515; -.
DR   eggNOG; COG1420; Bacteria.
DR   HOGENOM; CLU_050019_1_0_9; -.
DR   OMA; DYPGTMG; -.
DR   PhylomeDB; P0DJM4; -.
DR   BioCyc; LMON169963:LMO1475-MON; -.
DR   Proteomes; UP000000817; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IBA:GO_Central.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repressor; Stress response; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..345
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_0000182497"
SQ   SEQUENCE   345 AA;  39681 MW;  F3BFE25C1E415995 CRC64;
     MLTERQLLIF RAIIDHFTWT IQPVGSKNLL KEKGLPYSSA TIRNEMGVLE EYGFIEKTHS
     SSGRVPSEKG YRFYVDYLLQ PKKLDKSDRQ MIRSFFSENY YEMEGLIQNS ALMLSDLTNY
     TSILLGPEAT KNHLSGFRFV PINNFQAMLI LITDQGHVDN HLVTIPEGTT LSDIERMVNI
     LNERLVGLSL DDLKVQIPME VKELLGKHVR NYESFMHVFS DSFAQASQQK VYFGGKTNIL
     NQPEFHDINK VREMLHLMEE EQDVYELFRD IPDGLQVKIG RENNNSLMED CSIITATYNI
     AGERVGGIVL LGPTRMEYSR MMGLVDVMSR DLTDVLTKLY RDNQN