ID   HRCA_LYSSH              Reviewed;         343 AA.
AC   O69266;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 2.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081};
OS   Lysinibacillus sphaericus (Bacillus sphaericus).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Lysinibacillus.
OX   NCBI_TaxID=1421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 33203 / 1593;
RA   Ahmad S., Selvapandiyan A., Gasbarri M., Bhatnagar R.K.;
RL   Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; Y17157; CAA76661.1; -; Genomic_DNA.
DR   AlphaFoldDB; O69266; -.
DR   SMR; O69266; -.
DR   STRING; 1421.A2J09_11495; -.
DR   PRIDE; O69266; -.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Repressor; Stress response; Transcription; Transcription regulation.
FT   CHAIN           1..343
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_0000182447"
SQ   SEQUENCE   343 AA;  38817 MW;  EA09C6353533B451 CRC64;
     MLTNRQLQIL QVIIDDFILS AQPVGSRQIS KKQGITFSPA TIRNEMADLE ELGYLEKTHT
     SSGRVPSEKG YRFYVDHLLS PQGINSRDIQ QIQSIFNDRL VEVEHIIRKS ANILSELTSY
     TSILLGPDVQ RHRVKRFSIV PLSSDTAVAI IVTNNGHVEN RLFNLPPDFT ASDLEKMVNI
     LNDRLIGVSL EELHKSLEAE VLAVLQQHVQ SADDFYPRTR NSDNAIIQKA KIFYGGKTNM
     FNQPEFHDLN KVRMILDLME TTSQVQSLFH PNESGIHIRI GSENKQLEME NCSVITTTYS
     IGDDQQGAIA IIGPTRMDYK RVVALLDVIR LDLTQAFTKN RSE