ID   HRCA_MALP2              Reviewed;         338 AA.
AC   Q8EWX9;
DT   14-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=MYPE710;
OS   Malacoplasma penetrans (strain HF-2) (Mycoplasma penetrans).
OC   Bacteria; Tenericutes; Mycoplasmoidales; Mycoplasmoidaceae; Malacoplasma.
OX   NCBI_TaxID=272633;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HF-2;
RX   PubMed=12466555; DOI=10.1093/nar/gkf667;
RA   Sasaki Y., Ishikawa J., Yamashita A., Oshima K., Kenri T., Furuya K.,
RA   Yoshino C., Horino A., Shiba T., Sasaki T., Hattori M.;
RT   "The complete genomic sequence of Mycoplasma penetrans, an intracellular
RT   bacterial pathogen in humans.";
RL   Nucleic Acids Res. 30:5293-5300(2002).
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; BA000026; BAC43861.1; -; Genomic_DNA.
DR   RefSeq; WP_011076897.1; NC_004432.1.
DR   AlphaFoldDB; Q8EWX9; -.
DR   SMR; Q8EWX9; -.
DR   STRING; 272633.26453529; -.
DR   EnsemblBacteria; BAC43861; BAC43861; BAC43861.
DR   KEGG; mpe:MYPE710; -.
DR   eggNOG; COG1420; Bacteria.
DR   HOGENOM; CLU_050019_1_0_14; -.
DR   OMA; DYPGTMG; -.
DR   OrthoDB; 1510750at2; -.
DR   Proteomes; UP000002522; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repressor; Stress response; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..338
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_0000182509"
SQ   SEQUENCE   338 AA;  38867 MW;  55DFB476EA6A035D CRC64;
     MKEITQRQKE LLKYIVEDYV ATANPVGSKV VIEKYMPNIS AATVRNDMAF LEKLGLLEKN
     HTSSGRVPST AGYKFYEKNF SKPYINDENL KLKLRNVFAD RTMSIDVVIE ESCKIISEST
     KLPMIKIENN TEVLLKRIDM VEINKQSAMV IVITSDGNLT KNIIHFKDDS ILKDISICIR
     IFNDRLIDCP IKEIATKIDS MKSIIKEKVK EYEFVLQELI ERIFQIKSKM IKTVHGQSSL
     LAVPEFQDTE KLKEILQILE STSIWEQIAF KQNQTGSNTL ITFGDEVSHE DIVFAQTDLN
     INEQNKTKLV MVAPTRVDYS KIKGLLEFIK NEFEKGWK