ID   HRCA_MESFL              Reviewed;         342 AA.
AC   Q6F147;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 89.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=Mfl417;
OS   Mesoplasma florum (strain ATCC 33453 / NBRC 100688 / NCTC 11704 / L1)
OS   (Acholeplasma florum).
OC   Bacteria; Tenericutes; Mollicutes; Entomoplasmatales; Entomoplasmataceae;
OC   Mesoplasma.
OX   NCBI_TaxID=265311;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 33453 / NBRC 100688 / NCTC 11704 / L1;
RA   Birren B.W., Stange-Thomann N., Hafez N., DeCaprio D., Fisher S.,
RA   Butler J., Elkins T., Kodira C.D., Major J., Wang S., Nicol R., Nusbaum C.;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; AE017263; AAT75776.1; -; Genomic_DNA.
DR   RefSeq; WP_011183316.1; NC_006055.1.
DR   RefSeq; YP_053660.1; NC_006055.1.
DR   AlphaFoldDB; Q6F147; -.
DR   SMR; Q6F147; -.
DR   STRING; 265311.Mfl417; -.
DR   EnsemblBacteria; AAT75776; AAT75776; Mfl417.
DR   GeneID; 2898205; -.
DR   KEGG; mfl:Mfl417; -.
DR   PATRIC; fig|265311.5.peg.418; -.
DR   eggNOG; COG1420; Bacteria.
DR   HOGENOM; CLU_050019_1_0_14; -.
DR   OMA; DYPGTMG; -.
DR   Proteomes; UP000006647; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR005104; WHTH_HrcA_DNA-bd.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   Pfam; PF03444; HrcA_DNA-bdg; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repressor; Stress response; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..342
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_0000182498"
SQ   SEQUENCE   342 AA;  38985 MW;  B3BDA03ED005E215 CRC64;
     MLSERQAKIL KVIVSEYIKT NQAVSSKRIQ ELLNIKVSSA TIRNDSAALE EMNFLEKQHT
     SSGRVPSTKG YRYYVDHLME FDDYNESLKE NLKSILFQRG TKIENVLEQA SQIISEMTKM
     TAIVTKQNLN SELMVKKIDL IPLSETMASV IFILSNGEMQ NQLFNLKDIS LSDLSISIKI
     FSDCLVDTPV KEIENNISLI RPNLETTVKN YDLILETFMS NILQTKESKK EIVGMKNMLE
     NPEFNDTDKL RKVINIMENM SPFDWFDVSY SSNQKMIQIS TKIGEEISED LSDISIVETA
     IKTEQGSTML TLVGPKRVDY SQANQLINLI VEIINGDDHK NE