ID   HRCA_META1              Reviewed;         337 AA.
AC   B3PN01;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   02-SEP-2008, sequence version 1.
DT   03-AUG-2022, entry version 72.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   OrderedLocusNames=MARTH_orf618;
OS   Metamycoplasma arthritidis (strain 158L3-1) (Mycoplasma arthritidis).
OC   Bacteria; Tenericutes; Mycoplasmoidales; Metamycoplasmataceae;
OC   Metamycoplasma.
OX   NCBI_TaxID=243272;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=158L3-1;
RX   PubMed=18573899; DOI=10.1128/iai.00516-08;
RA   Dybvig K., Zuhua C., Lao P., Jordan D.S., French C.T., Tu A.H.,
RA   Loraine A.E.;
RT   "Genome of Mycoplasma arthritidis.";
RL   Infect. Immun. 76:4000-4008(2008).
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; CP001047; ACF07403.1; -; Genomic_DNA.
DR   RefSeq; WP_012498360.1; NC_011025.1.
DR   AlphaFoldDB; B3PN01; -.
DR   SMR; B3PN01; -.
DR   STRING; 243272.MARTH_orf618; -.
DR   EnsemblBacteria; ACF07403; ACF07403; MARTH_orf618.
DR   KEGG; mat:MARTH_orf618; -.
DR   eggNOG; COG1420; Bacteria.
DR   HOGENOM; CLU_050019_1_0_14; -.
DR   OMA; DYPGTMG; -.
DR   OrthoDB; 1510750at2; -.
DR   Proteomes; UP000008812; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repressor; Stress response; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..337
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_1000092818"
SQ   SEQUENCE   337 AA;  38259 MW;  EF59456194FA9834 CRC64;
     MEKRTNYPQL TEKQNHFFKL IVDTYIKTGA SVASKELVKR CNLKCSSATI RNVMASLEQI
     GFLEKYHISS GRVPSTLGLE YYAKFLVYNP KKYFDQKLED LLAKRRIKID ATLEEAAAIV
     SEVAGVTVVA TSNNAAETMK SIQLTTLSEL SAIVVIVTSS GRVESKIFNF ENSDISLEDL
     RVAIRLFKER LVDTPLIHLA NKARALTPIF GQQLKNYELI LQKFIKNIFV FEEETTNKTF
     NKGAIVLSRN ISREEIANVL DLIEKHSVWE SIDNDLDEDN NIKLDVSRPN LSIISKKIDF
     SNEKNIKEIT VIGPNNLDYG ESFEALEMLE KIIKEKK