ID   HRCA_MOOTA              Reviewed;         344 AA.
AC   Q2RKX6;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 1.
DT   25-MAY-2022, entry version 97.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=Moth_0583;
OS   Moorella thermoacetica (strain ATCC 39073 / JCM 9320).
OC   Bacteria; Firmicutes; Clostridia; Thermoanaerobacterales;
OC   Thermoanaerobacteraceae; Moorella group; Moorella.
OX   NCBI_TaxID=264732;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 39073 / JCM 9320;
RX   PubMed=18631365; DOI=10.1111/j.1462-2920.2008.01679.x;
RA   Pierce E., Xie G., Barabote R.D., Saunders E., Han C.S., Detter J.C.,
RA   Richardson P., Brettin T.S., Das A., Ljungdahl L.G., Ragsdale S.W.;
RT   "The complete genome sequence of Moorella thermoacetica (f. Clostridium
RT   thermoaceticum).";
RL   Environ. Microbiol. 10:2550-2573(2008).
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; CP000232; ABC18913.1; -; Genomic_DNA.
DR   RefSeq; WP_011392120.1; NC_007644.1.
DR   RefSeq; YP_429456.1; NC_007644.1.
DR   AlphaFoldDB; Q2RKX6; -.
DR   SMR; Q2RKX6; -.
DR   STRING; 264732.Moth_0583; -.
DR   EnsemblBacteria; ABC18913; ABC18913; Moth_0583.
DR   GeneID; 61289274; -.
DR   KEGG; mta:Moth_0583; -.
DR   PATRIC; fig|264732.11.peg.627; -.
DR   eggNOG; COG1420; Bacteria.
DR   HOGENOM; CLU_050019_1_0_9; -.
DR   OMA; DYPGTMG; -.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Repressor; Stress response; Transcription; Transcription regulation.
FT   CHAIN           1..344
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_1000010422"
SQ   SEQUENCE   344 AA;  38865 MW;  3AFA7B75D41EF97B CRC64;
     MRMDERKQKV LAAVIQDYIL TGEPVGSRTI ARRYNLGVSP ATIRNEMADL EEMGLLEQPH
     TSAGRIPSDQ GYRYYVDCLM PPAHLTPEEE EYVRRRYNQK MLEIEQVLAE TTRLISEMTS
     YAAIALGPDQ GRASLEEVQV LPIQVANKAL LVAVTSTGVV EHRVLTIPEG VTPEDLNRIS
     RVLNARLQGR ALEDLRQMVL SDIYQELAQH RNLVNLVRDL LQQLLSLESG ERVYRNGTLN
     ILNQPEFKDL DRVREILSFL DQDEALRRIF MTTPSTGLTI RIGQENKIEG IDKCSVVTIS
     YAVEGKIMGK VGLLGPTRMQ YSRAISVLRC VADALSQTLE QLYR